Synthetic Microbial Community Promotes Bacterial Communities Leading to Soil Multifunctionality in Desertified Land.

Soil desertification is an important challenge in global soil management, and effectively and stably restoring soil function is an urgent problem. Using synthetic microbial communities (SynComs) is a burgeoning microbial strategy aimed at enhancing soil nutrients through functional synergies among diverse microorganisms; nevertheless, their effectiveness in restoring desertified soils remains unknown. In this study, we conducted a two-year field experiment using a SynCom constructed by in situ probiotic bacteria and set up control, chemical fertilizer, and combined SynCom-chemical fertilizer (combined fertilizer) treatments to investigate the linkage between microbial communities and soil multifunctionality in the soil surface layer (0-10 cm).

Field Manipulations in On-Chip Micro/Nanoscale Lasers Based on Colloid Nanocrystals.

Owning to merits such as bandgap tunability, solution processability, large absorption coefficients, and high photoluminescence quantum yields, colloidal quantum dots (CQDs) emerged as a promising gain material to make on-chip micro/nanoscale lasers with high silicon compatibility. In this paper, we review the recent progress in CQD on-chip micro/nanoscale lasers, with a special focus on the physical properties achieved through field manipulation schemes in different types of cavities. Key aspects include manipulating and engineering wavelength, polarization, and direction as well as coupling and light extraction.

Exosomal LINC00355 promotes the malignant progression of gastric cancer through histone deacetylase HDAC3-mediated TP53INP1 transcriptional inhibition.

Aims: Exosomes are a subpopulation of extracellular vesicles (EV) derived from multivesicular body (MVB) that transmit various cellular molecular constituents, including long noncoding RNAs (lncRNAs), to promote intercellular communication. Our aim was to investigate the function and mechanism of exosomal LINC00355 in gastric cancer cells.

Main Methods: Exosomal levels of LINC00355 in GC patients and healthy controls were measured by RT-qPCR.

Design, synthesis and biological evaluation of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine scaffold as DFG-out B-Raf kinase inhibitors.

By combining the scaffolds of UI-125 and Sorafenib, a series of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine moiety were designed and synthesized as novel DFG-out B-Raf(V600E) inhibitors. Among them, 20c-e, 20g and 21h displayed potent antiproliferative activities against melanoma A375 (B-Raf(V600E)) cell lines with IC50 values of 3.190, 2.