Publications by authors named "Yazhi Zhong"
Sepsis-associated encephalopathy is a severe systemic infection complication. Although early stages involve pathophysiological changes, detection using conventional imaging is challenging. Glutamate chemical exchange saturation transfer and diffusion kurtosis imaging can noninvasively investigate cellular and molecular events in early disease stages using magnetic resonance imaging (MRI).
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- - A study explored using angiopep-2 (ANG) as an imaging biomarker to detect amyloid β-protein (Aβ) deposition in mice with Alzheimer's disease, which could help improve early prognosis.
- - ANG demonstrated a strong chemical exchange saturation transfer (CEST) effect and a moderate affinity for Aβ, significantly improving detection of Aβ deposition in 6-month-old AD mice compared to controls.
- - The findings suggest that ANG's CEST could effectively identify early Aβ-related changes in AD progression, making it a promising tool for diagnosing and monitoring Alzheimer's disease non-invasively.
Stroke is the second leading cause of death globally and the most common cause of severe disability. Several barriers need to be addressed more effectively to treat stroke, including efficient delivery of therapeutic agents, rapid release at the infarct site, precise imaging of the infarct site, and drug distribution monitoring. The present study aimed to develop a bio-responsive theranostic nanoplatform with signal-amplifying capability to deliver rapamycin (RAPA) to ischemic brain tissues and visually monitor drug distribution.
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