Personalized dosimetry assessment of [Lu]Lu-PSMA-617 radioligand therapy in the management of metastatic castration-resistant prostate cancer.

Introduction: Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) is revolutionizing the treatment landscape for metastatic castration-resistant prostate cancer (mCRPC) patients. This study aimed to establish patient-specific radiation dosimetry for [Lu]Lu-PSMA-617 RLT in Iranian patients with mCRPC.

Method: Twelve biopsy-proven prostate cancer patients (aged 68.

Enhanced third-order nonlinear optical properties of ZnO@C-N composite microspheres.

We report the third-order nonlinear optical (NLO) properties of ZnO@C-N composite microspheres and pure ZnO which have been investigated with the Z-scan technique under continuous wave laser. ZnO@C-N composite microspheres have been hydrothermally synthesized at two different precursor concentrations to have structures at different impurity levels. Moreover, pure ZnO is prepared under the annealing process.

A step toward simplified dosimetry of radiopharmaceutical therapy via SPECT frame duration reduction.

Despite being time-consuming, SPECT/CT data is necessary for accurate dosimetry in patient-specific radiopharmaceutical therapy. We investigated how reducing the frame duration (FD) during SPECT acquisition can simplify the dosimetry workflow for [Lu]Lu-PSMA radioligand therapy (RLT). We aimed to determine the impact of shortened acquisition times on dosimetric precision.

Association of inflammatory biomarkers with overall survival in burn patients: a systematic review and meta-analysis.

Introduction: The inflammatory response to burn injuries can lead to organ dysfunction that ultimately results in increased mortality and morbidity. This meta-analysis was conducted to determine the efficacy of inflammatory biomarkers, including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), procalcitonin (PCT), and C-reactive protein (CRP) as predictive tools of mortality among burn patients.

Material And Methods: The biomarker levels of survivors and non-survivors were consolidated according to guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

Automated segmentation of lesions and organs at risk on [Ga]Ga-PSMA-11 PET/CT images using self-supervised learning with Swin UNETR.

Background: Prostate-specific membrane antigen (PSMA) PET/CT imaging is widely used for quantitative image analysis, especially in radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC). Unknown features influencing PSMA biodistribution can be explored by analyzing segmented organs at risk (OAR) and lesions. Manual segmentation is time-consuming and labor-intensive, so automated segmentation methods are desirable.

Radiomics and Artificial Intelligence in Radiotheranostics: A Review of Applications for Radioligands Targeting Somatostatin Receptors and Prostate-Specific Membrane Antigens.

Radiotheranostics refers to the pairing of radioactive imaging biomarkers with radioactive therapeutic compounds that deliver ionizing radiation. Given the introduction of very promising radiopharmaceuticals, the radiotheranostics approach is creating a novel paradigm in personalized, targeted radionuclide therapies (TRTs), also known as radiopharmaceuticals (RPTs). Radiotherapeutic pairs targeting somatostatin receptors (SSTR) and prostate-specific membrane antigens (PSMA) are increasingly being used to diagnose and treat patients with metastatic neuroendocrine tumors (NETs) and prostate cancer.

Understanding the influence of cation and anion migration on perovskite light-emitting diodes via transient response.

Despite the rapid progress demonstrated in the efficiency of Perovskite light-emitting diodes (PeLEDs) in the past few years, ion migration has challenged the practical applications of these devices with undesirable hysteresis and degradation effect. Mobile ions in PeLEDs induced many unique and fast transient phenomena occurring on the time scale of microseconds to seconds and it is still far from clear how the underlying physical mechanism of ion motion-induced variation relates to the device performance. Therefore, in this work, we employ an ionic Drift-Diffusion Model (DDM) to evaluate measuring transient current response in a time scale of sub-seconds.

The effect of perovskite interface contacts on hysteresis behavior in perovskite solar cells.

The ionic-electronic drift-diffusion model is employed to simulate the hysteresis behavior in perovskite solar cells (PSCs) under low-to-moderate conditions; the migrating ions stop at the HTL/ETL interfaces. However, for high-applied bias voltage, illumination, air exposure for weeks, and special cell configuration, these ions can also reach the external contact interfaces, presenting anomalous hysteresis behavior. This has already been confirmed experimentally but has not been modeled yet.

Comparing the Effectiveness of Bupivacaine Administration through Chest Tube and Intercostal Blockage in Patients with Rib Fractures.

Background: There are several methods to control pain, especially in traumatic patients with rib fractures. Intrapleural analgesia (IPA) and intercostal block methods are recommended in patients with rib fractures to control pain. Here, we aimed to evaluate and compare the effects of IPA and intercostal block on patients' clinical conditions.

Tumor-derived exosomal non-coding RNAs as diagnostic biomarkers in cancer.

Almost all clinical oncologists agree that the discovery of reliable, accessible, and non-invasive biomarkers is necessary to decrease cancer mortality. It is possible to employ reliable biomarkers to diagnose cancer in the early stages, predict the patient prognosis, follow up the response to treatment, and estimate the risk of disease recurrence with high sensitivity and specificity. Extracellular vesicles (EVs), especially exosomes, have been the focus of translational research to develop such biomarkers over the past decade.

Comprehensive study of anomalous hysteresis behavior in perovskite-based solar cells.

Perovskite solar cells (PSCs) have shown remarkable progress with the rapid increase in power conversion efficiency to reach 25.7% over the last few years. However, it is difficult to precisely determine the energy conversion efficiency for PSC, because of anomalous current density-voltage (J-V) hysteresis.

A recombinant affitoxin derived from a HER3 affibody and diphteria-toxin has potent and selective antitumor activity.

High expression of receptor tyrosine-protein kinase erbB-3 (HER3) has been found in several malignancies such as breast cancer. In this study, we designed, produced and evaluated a new affitoxin consisting of a truncated form of diphtheria toxin and a HER3-binding affibody domains. The new affitoxin was expressed in Escherichia coli and purified by affinity chromatography.

The role of endoplasmic reticulum stress in the regulation of long noncoding RNAs in cancer.

Cancer cells must overcome a variety of external and internal stresses to survive and proliferate. These unfavorable conditions include the accumulation of mutations, nutrient deficiency, oxidative stress, and hypoxia. These stresses can cause aggregation of misfolded proteins inside the endoplasmic reticulum.

Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment.

Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms.

Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer.

The assertion that a significant portion of the mammalian genome has not been translated and that non-coding RNA accounts for over half of polyadenylate RNA have received much attention. In recent years, increasing evidence proposes non-coding RNAs (ncRNAs) as new regulators of various cellular processes, including cancer progression and nerve damage. Apoptosis is a type of programmed cell death critical for homeostasis and tissue development.

Narrow-band random Raman lasing from Rhodamine 6G assisted by cascaded stimulated Raman scattering effect.

This study reports the first experimental observation of cascaded stimulated Raman scattering (SRS) generation in a colloidal disordered medium. Generation of the cascaded effect requires both a high Raman gain and pump power in the disordered medium. Here, to extend effective path lengths of photons into the Raman gain medium for producing additional SRS processes, ZnO microspheres with abundant nano-protrusions as suitable scattering centers are proposed.

Development of neoantigens: from identification in cancer cells to application in cancer vaccines.

Introduction: The discovery of neoantigens as mutated proteins specifically expressed in tumor cells but not in normal cells has led to improved cancer vaccines. Targeting neoantigens can induce anti-tumor T-cell responses to destroy tumors without damaging healthy cells. Extensive advances in genome sequencing technology and bioinformatics analysis have made it possible to discover and design effective neoantigens for use in therapeutic cancer vaccines.

Third-Order Nonlinear Optical Behavior of an Amide-Tricarboxylate Zinc(II) Metal-Organic Framework with Two-Fold 3D+3D Interpenetration.

A new metal-organic framework (MOF), [Zn(μ-O)(μ-L)(HO)]·DMF (ZSTU-10), was assembled from zinc(II) nitrate and ,',″-bis(4-carboxylate)trimesicamide linkers and fully characterized. Its crystal structure discloses an intricate two-fold 3D+3D interpenetrated MOF driven by the [Zn(μ-O)]-based tetragonal secondary building units and the C3-symmetric tris-amide-tricarboxylate linkers (μ-L). Topological analysis of ZSTU-10 reveals two interpenetrated 3,6-connected nets with an (rutile) topology.

Efficiency enhancement of CZTSSe solar cells via screening the absorber layer by examining of different possible defects.

This study represents the investigation of earth-abundant and non-toxic CZTSSe absorber materials in kesterite solar cell by using the Finite Element Method (FEM) with (1) electrical, and (2) optical approaches. The simulated results have been validated with the experimental results to define guidelines for boosting the cell performance. For improving the cell efficiency, potential barrier variations in the front contact, and the effect of different lattice defects in the CZTSSe absorber layer have been examined.

Preparation and Evaluation of Possible Antioxidant Activities of Rose Traditional Tablet"(Qurs-e-Vard)" A Selected Traditional Persian Medicine (TPM) Formulation via Various Procedures.

Background: Free radicals can lead to liver dysfunction. Quality control of traditional formulations ensures their safe, pure, and pharmaceutical efficacy. "Qurs-e-Vard", containing petals of Rosa damascena Mill.

Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.

Developmental neurotoxicity of a wide variety of toxicants mediated via maternal exposure during gestation is very well established. In contrast, the impacts of paternal toxicant exposure on offspring neurobehavioral function are much less well studied. A vector for paternal toxicant exposure on development of his offspring has been identified.

Study of waste tire pyrolysis in a rotary kiln reactor in a wide range of pyrolysis temperature.

Thermal pyrolysis of waste tires without metals has been studied in a rotating kiln reactor under nitrogen atmosphere. The pyrolysis temperature was varied in a wide range from 400 up to 1050 °C to investigate the effect of temperature on pyrolysis products. The pyrolytic oil during each pyrolysis process was reported in different pyrolysis times.

Effect of containing silica fume on cytotoxicity of white mineral trioxide aggregate.

Background: Mineral trioxide aggregate (MTA) has a high biocompatibility and its physical properties could be improved by adding the containing silica fume an amorphous silicon dioxide (condensed silica fume [CSF]). The aim of this study was to evaluate the cytotoxicity of MTA mixed with CSF on the viability of L929 mouse fibroblast cell using 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide reduction assay (MTT assay).

Materials And Methods: In this study white MTA was mixed with distilled water according to the manufacturer's instructions.

Artificial Ureter in Patients with Extensive Ureteral Damage.

Purpose: loss of significant lengths of ureter when substitution with bowel or bladder fails is a disaster in urology. This study is conducted to evaluate the results of subcutaneous nephron-vesical bypass (SNVB) in ureteral damage of different etiologies.

Materials And Methods: Seventeen SNVB were employed in patients with ureteral injuries.

Application of methyl silane coated iron oxide magnetic nanoparticles for solid-phase extraction and determination of fat-soluble vitamins by high performance liquid chromatography.

Methyl silane coated Fe3O4 magnetic nanoparticles were used for simultaneous extraction of the fat-soluble vitamins (FSVs). The amounts of extracted vitamins were determined by HPLC. The synthesized Fe3O4 nanoparticles were coated with silica and then modified with trimethoxymethylsilane (TMMS).