Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-Specific Pathways.

Significance Statement: Ischemia-reperfusion AKI (IR-AKI) is common and causes significant morbidity. Effective treatments are lacking. However, preclinical studies suggest that inhibition of angiopoietin-Tie2 vascular signaling promotes injury, whereas activation of Tie2 is protective.

Dialytic interval and the timing of electrocardiographic screening for subcutaneous cardioverter-defibrillator placement in chronic hemodialysis patients.

Background: Hemodialysis (HD) patients have a high risk of sudden death but limited vascular access and high complication rates from transvenous implantable cardioverter-defibrillators (ICDs). Subcutaneous ICDs (S-ICD) may be an alternative, but dynamic ECG changes may result in inappropriate shocks. This study aims to define the screen failure rate for S-ICD in patients pre- and post-HD.

A case of symptomatic deep vein thrombosis mimicking occlusive peripheral arterial disease.

Peripheral arterial disease (PAD) and acute deep vein thrombosis (DVT) can both result in similar calf pain presentation. Treatment modalities depend on the etiology of the pain. We present the case of a 63-year-old female with left lower extremity pain and describe our eventual diagnosis of DVT as the cause of her symptoms.