Biodegradable polyurethane micelles with pH and reduction responsive properties for intracellular drug delivery.

Polyurethane micelles with disulfide linkage located at the interface of hydrophilic shell and hydrophobic core (PU-SS-I) have been shown enhanced drug release profiles. However, the payloads could not be released completely. The occurrence of aggregation of hydrophobic cores upon shedding hydrophilic PEG coronas was considered as the reason for the incomplete release.

Antibacterial and antifouling properties of a polyurethane surface modified with perfluoroalkyl and silver nanoparticles.

Inspired by mussel-adhesion phenomena in nature, a simple, mild surface modification process was elaborated to endow the polyurethane (PU) substrate with antibacterial/antifouling properties. In the present study, polydopamine was coated directly onto polyurethane surfaces. AgNO was then added and absorbed onto the surface by the active catechol and amine groups of the polydopamine coating.