Publications by authors named "Yayoi Matoba"
Introduction: A reduced salt intake is a vital lifestyle modification in the management of hypertension. Initiatives aimed at decreasing the intake of salt are based on the preference by humans for a salt taste. Salt intake behavior appears to be affected by the balance between attraction to a low salt taste and aversion to a high salt taste.
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- * Researchers created a mouse model that mimics advanced DKD and found significant tissue damage, inflammation, and high levels of VCAM1 in the kidneys, which reflects the condition in humans.
- * The drug luseogliflozin was shown to improve kidney health by reducing tissue hypoxia and inflammation, highlighting the potential of VCAM1 as a marker and SGLT2 inhibitors as a treatment option for advanced DKD.
Article Synopsis
- Streptozotocin (STZ) is mainly used as an anti-cancer drug for treating neuroendocrine tumors (NETs) but can also cause DNA damage in kidney cells, leading to injury.
- Research showed that this kidney damage is linked to the activation of the p53 signaling pathway and reduced membrane transporters in tubular epithelial cells.
- Treatment with an SGLT2 inhibitor can help protect kidney cells from STZ-induced damage without affecting the drug's effectiveness on pancreatic β-cells, suggesting its potential as a preventative treatment for kidney injury in NET patients.
A 64-year-old male was admitted to hospital because of repeated episodes of syncope and palpitation. Ambulatory monitoring revealed paroxysmal atrial fibrillation (AF) as the cause of palpitation; he did not have structural heart disease. The induction of AF by rapid pacing (50 Hz for 1 s) in an upright position provoked syncope with a vasodepressor response.
View Article and Find Full Text PDFA 69-year-old woman was admitted to our hospital for the examination of syncope. When she ate solid food, she had dizziness or loss of consciousness. The ambulatory ECG suggested sino-atrial block during swallowing with a maximum sinus pause of 6 seconds.
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