Publications by authors named "Yaying Zhai"
Article Synopsis
- The study investigates the effects of Alpha-Ketoglutarate (AKG) on cumulus oocyte complexes (COCs) during in vitro maturation (IVM), highlighting its dose-dependent benefits and drawbacks.
- At an optimal concentration of 30 µM, AKG enhances cumulus expansion, oocyte quality, and embryo development by reducing oxidative stress and improving mitochondrial function.
- Conversely, a higher concentration of 750 µM negatively impacts these processes, although GDF9 supplementation can counteract some of the adverse effects caused by higher AKG levels.
The diagnosis of ewes' pregnancy status at an early stage is an efficient way to enhance the reproductive output of sheep and allow producers to optimize production and management. The techniques of proteomics and metabolomics have been widely used to detect regulatory factors in various physiological processes of animals. The aim of this study is to explore the differential metabolites and proteins in the serum of pregnant and non-pregnant ewes by proteomics and metabolomics.
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- The study investigates the role of microRNAs (miRNAs) found in intrauterine exosomes and their impact on embryo development and implantation during bovine pregnancy.
- Researchers collected and analyzed exosomes from cows 7 days post-fertilization, discovering significant differences in miRNA expression levels between donor and recipient cows.
- The findings suggest that these miRNAs play a crucial role in the processes related to embryo implantation and could help improve understanding of the uterine environment necessary for successful pregnancies in cattle.
Embryonic mortality is considered to be one of the main reasons for reduced conception rates in the cattle industry. Insufficient endometrial receptivity is a major factor resulting in embryo implantation failure and losses. Apoptosis of endometrial epithelial cells is an important process during establishment of uterine receptivity and embryo implantation.
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