Fingerstick blood assay maps real-world NAD disparity across gender and age.

Nicotinamide adenine dinucleotide (NAD ) level has been associated with various age-related diseases and its pharmacological modulation emerges as a potential approach for aging intervention. But human NAD landscape exhibits large heterogeneity. The lack of rapid, low-cost assays limits the establishment of whole-blood NAD baseline and the development of personalized therapies, especially for those with poor responses towards conventional NAD supplementations.

represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia.

The microRNAs and - are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the gene in mice causes mild anemia under baseline conditions. Here we show that erythroblasts exhibit increased apoptosis during recovery from acute anemia.

miR-451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal cancer.

Background And Objective: Our previous studies reported that miR-451 could protect against erythroid oxidant stress target gene-Ywhaz (14-3-3zeta) via inhibiting FoxO3 in the erythropoiesis. This study aimed to investigate the potential mechanism underlying the regulatory effect of miR-451 on human colorectal cancer (CRC) cells.

Methods: In this study, expressions of miR-451 and Ywhaz in CRC tissues and adjacent normal tissues were detected by quantitative real-time PCR (qRT-PCR) and immunohistochemistry respectively.