Publications by authors named "Yaye Wang"

Background: Myasthenia gravis (MG) is an autoimmune neuromuscular disease marked by dysregulation of several immune cell populations. Here we explored peripheral immune landscape, particularly the role of low-density granulocytes (LDGs).

Methods: Single-cell and bulk RNA sequencing analyzed peripheral immune cells from MG patients pre- (n = 4) and after treatment (n = 2), as well as healthy controls (n = 3).

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Previous studies have indicated the great performance of electrooxidation (EO) to mineralize per- and polyfluoroalkyl substances (PFASs) in water, but different anions presented in wastewater may affect the implementation of EO treatment in field applications. This study invetigated EO treatment of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), two representative perfluoroalkyl acids (PFAAs), using porous Magnéli phase titanium suboxide anodes in electrolyte solutions with different anions present, including NO3-, SO42-, CO32- and PO43-. The experiment results indicate that CO32- enhanced PFAS degradation, while NO3- suppressed the degradation reactions with its concentration higher than 10 mM.

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Background: Very-late-onset myasthenia gravis (VLOMG) refers to myasthenia gravis (MG) with onset at age 65 or older. Current research on VLOMG prognosis remains limited, especially regarding factors influencing outcomes.

Objectives: To identify the clinical factors that affect the short- and long-term prognosis of MG patients with an onset age ⩾65 years.

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Article Synopsis
  • The study explored the safety of COVID-19 vaccines for patients with Myasthenia Gravis (MG) and examined factors affecting MG exacerbation after COVID-19 infection.
  • Among the 1013 adult MG patients surveyed, only a small percentage experienced exacerbation following vaccination, while a notable number faced exacerbation after COVID-19 infection, particularly those with generalized MG.
  • The findings suggest that COVID-19 vaccines are generally safe for MG patients in stable condition, but those with generalized MG may be at higher risk for exacerbation following infection.
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  • Structural variants (SVs) are rarely found in Duchenne muscular dystrophy (DMD), which is usually characterized by deletions and point mutations in the DMD gene, making detection challenging with standard short-read sequencing.
  • A family case is presented where a boy with symptoms of muscular dystrophy had no visible abnormalities in the DMD gene using routine techniques, but analysis of dystrophin mRNA revealed missing exons 59 to 79.
  • Advanced long-read whole-genome sequencing ultimately identified a complex structural variant and a translocation within the DMD gene, highlighting the need to consider SVs in molecular diagnostics when other methods fail.
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This study systematically investigated the variable main electrooxidation mechanism of chlorophene (CP) and dichlorophen (DCP) with the change of reaction conditions at TiO anode operated in batch and reactive electrochemical membrane (REM) modes. Significant degradation of CP and DCP was observed, that is, CP exhibited greater removal efficiency in batch mode at 0.5-3.

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Background: The environmental effects on the prognosis of ocular myasthenia gravis (OMG) remain largely unexplored.

Aim: To investigate the association between specific environmental factors and the generalization of OMG.

Design: The cohort study was conducted in China based on a nationwide multicenter database.

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Background: Frontotemporal dementia (FTD) has genetic heterogeneity, and the endosomal ESCRTIII-complex subunit CHMP2B variant is a rare cause of FTD. The mutations in CHMP2B were first identified in a large Danish pedigree with autosomal dominant FTD, and have also been found in several individuals from Belgium, France, the United States, and Türkiye. In the Chinese population, cases of CHMP2B variant-associated FTD have never been reported.

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Polyglucosan body myopathy type 1 (PGBM1, OMIM #615895.) is a rare autosomal recessive disorder caused by RBCK1 mutations. The patients displayed polyglucosan accumulation in skeletal and cardiac muscles, giving rise to loss of ambulation and heart failure with or without immune system dysregulation.

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Article Synopsis
  • Meningoencephalocele is a rare condition where part of the brain bulges out due to problems in the skull and is linked to repeated brain infections.
  • This case study talks about a patient who had meningitis many times over ten years and was found to have meningoencephalocele because of high pressure in the brain.
  • After taking a medication to lower the pressure, the patient did not have any more meningitis symptoms for six months.
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Formation of chlorate (ClO) and perchlorate (ClO) as by-products in electrooxidation process has raised concern. In the present study, the formation of ClO and ClO in the presence of 1.0 mM Cl on boron doped diamond (BDD) and Magneli phase titanium suboxide (TiO) anodes were evaluated.

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Electrooxidation (EO) has been shown effective in degrading per- and polyfluoroalkyl substances (PFASs) in water, but concurrent formation of chlorate and perchlorate in the presence of chloride is of concern due to their toxicity. This study examined EO treatment of three representative PFASs, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and 6:2 fluorotelomer sulfonate (6:2 FTS), in chloride-containing solutions on pristine and surface-fluorinated TiO anodes having different percentage of surface fluorination. The experiment results indicate that surface fluorination of TiO anodes slightly inhibited PFAS degradation, while significantly decreased the formation of chlorate and perchlorate.

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DNAJB6 was identified as the causative gene of limb-girdle muscular dystrophy type 1D. In recent years, the phenotypic and molecular spectrum of DNAJB6-myopathy has been expanded, and several mutations of DNAJB6 have been identified in Europe, North America, and Asia. Interestingly, almost all identified mutations in previous reports were point mutations, and most of them were clustered in exon 5, which encodes the G/F domain of DNAJB6.

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Aims: To evaluate the clinical, pathological, and genetic features of patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (RR-MADD).

Methods: Thirty-one patients with RR-MADD admitted to our hospital from January 2005 to November 2020 were enrolled, and their clinical data were collected. Pathological characteristics of the muscle tissue and possible pathogenic gene mutations were analyzed.

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Background: Hereditary spastic paraplegia 7 (SPG7) is one of the subtypes of autosomal-recessive hereditary spastic paraplegia, which is a clinically heterogeneous neurodegenerative disorder. SPG7 often displays a complicated phenotype, including optic atrophy, ophthalmoparesis, and impaired emotional communication. In the Chinese population, sporadic cases of SPG7 variant-associated spastic ataxia are rarely reported.

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The effect of electrochemical degradation on Magnéli phase TiO anode combined with UV irradiation on the removal of PFOS was systematically evaluated in the present study. A synergistic effect of electrolysis and UV irradiation rather than a simple additive effect for PFOS degradation was demonstrated experimentally and theoretically. The short wavelength irradiation within 400 nm is the main contribution to enhance the electrochemical degradation of PFOS, while the initial pH of the solution has little effect on the PFOS degradation.

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Background: Inclusion body myositis (IBM) is a unique idiopathic inflammatory myopathy with unclear pathogenesis and poor prognosis. Although previous publications have identified some molecular biomarkers, the value of these biomarkers is unknown.

Objective: To identify hub genes and signaling pathways related to IBM for understanding the IBM-related mechanisms and providing guidance for therapy development.

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This study examined the feasibility of a novel treatment train that combines electrocoagulation (EC) with electrooxidation (EO) treatment to remove and degrade per- and polyfluoroalkyl substances (PFASs) from water. Electrocoagulation with a zinc anode could effectively remove PFASs from water, and long-chain PFASs (C-C) tended to have a higher removal rate. Foam was generated when a relatively high current density (>1 mA cm) was applied to a relatively high PFAS concentration (each PFAS > 0.

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Reversible splenial lesion syndrome (RESLES) is a rare clinical imaging syndrome that is characterized by magnetic resonance imaging (MRI) findings of reversible abnormal signals in the splenium of the corpus callosum (SCC). There are a variety of pathogenic causes, including infection, metabolic disturbances, and antiepileptic drug use. Moreover, the disease is clinically rare and easily misdiagnosed.

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We report a family with riboflavin-reactive multiple acyl-CoA dehydrogenase deficiency (RR-MADD) partially caused by a novel mutation in the electron transfer flavoprotein dehydrogenase gene ). The RR-MADD family was identified by physical examination, electromyography, and muscle biopsy of the proband. Laboratory examination and electromyography suggested a muscle disease of the lipid storage myopathies.

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NLSDM is a rare metabolic myopathy caused by mutations in the patatin-like phosphatase domain protein 2 (PAPLA2) genes. In the present study, we describe the clinical and genetic findings in our Chinese patient with NLSDM. Sequence analysis of PNPLA2 gene was performed.

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In this study, the post-treatment of biologically treated acrylonitrile wastewater was investigated during UV/HO process. Five contaminants in the effluent were selected as target compounds, including Furmaronitrile (FMN), 3-Pyridinecarbonitrile (3PCN), 1,3-Dicyanobenzene (1,3-DCB), 5-Methyl-1H-benzotriazole (5MBT), and 7-Azaindole (7AID). Under optimal reaction conditions, the UV/HO post-treatment exhibited good performances in destruction of organic compounds and toxicity.

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This study examined the degradation of perfluorooctanesulfonate (PFOS) in an electrochemical system using Magnéli phase titanium suboxide (TiO) as the anode. In particular, the influence of chloride on the treatment process was examined. Tests were also conducted with boron doped diamond (BDD) electrodes for comparison.

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This study investigated the degradation of perfluorooctanesulfonate (PFOS) in a reactive electrochemical membrane (REM) system in which a porous Magnéli phase titanium suboxide ceramic membrane served simultaneously as the anode and the membrane. Near complete removal (98.30 ± 0.

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