The impact of amygdala glutamate receptors on cardiovascular function in rats with post-traumatic stress disorder.

Post-traumatic stress disorder (PTSD) has been reported to be associated with a higher risk of cardiovascular disease. The amygdala may have an important role in regulating cardiovascular function. This study aims to explore the effect of amygdala glutamate receptors (GluRs) on cardiovascular activity in a rat model of PTSD.

Synthesis, Crystal Structure, and the Deep Near-Infrared Absorption/Emission of Bright AzaBODIPY-Based Organic Fluorophores.

Annularly fused azaBODIPY-based organic fluorophores (HBPs 2) containing up to 13 aromatic ring fusions were synthesized by a Suzuki coupling reaction with bromoazadipyrromethenes and a subsequent regioselective oxidative ring-fusion reaction. X-ray analysis indicates almost planar dipyrrin cores for all crystals but overall curved or "wave" conformations for those HBP dyes. These molecules exhibit unique structural and physical properties including excellent spectral selectivity (negligible absorption between 300 and 700 nm), sharp near-infrared (NIR) absorption (up to 878 nm) and emission (up to 907 nm), large extinction coefficient (up to 4.

Synthesis, Structure, and Properties of β-Vinyl Ketone/Ester Functionalized AzaBODIPYs from FormylazaBODIPYs.

Postfunctionalization of azaBODIPY (the BF complex of azadipyrromethene) is highly desirable due to the strong tunable absorption bands at wavelengths above 650 nm and the wide-ranging applications of this class of dyes in biomedicine and materials science. Currently available postfunctionalization methods for this class of dyes have been limited to the Pd-catalyzed coupling reactions on β-halogenated (brominated or iodinated) azaBODIPY platforms. In this work, we report a new strategy for the facile postfunctionalization of the azaBODIPY chromophore with various vinyl ketone and vinyl esters based on a Wittig reaction on our previously developed β-formylazaBODIPYs and our recently developed β-bromo-β'-formylazaBODIPYs.

Synthesis, Properties, and Semiconducting Characteristics of BF Complexes of β,β-Bisphenanthrene-Fused Azadipyrromethenes.

Three novel π-extended BF complexes of β,β-bisphenanthrene-fused azadipyrromethenes containing nine fused rings have been synthesized on the basis of a tandem Suzuki coupling reaction on readily available 2,6-dibromoazaBODIPYs followed by an intramolecular oxidative aromatic coupling mediated by iron(III) chloride. These resultant BF complexes exhibit strong absorption (extinction coefficients up to 2.4 × 10 M cm) and emission in the near-infrared (NIR) range (790-816 nm) with excellent photo and thermal stabilities.

Accessing near-infrared-absorbing BF2-azadipyrromethenes via a push-pull effect.

Novel aza-BODIPYs with significant bathochromic shifts were designed and synthesized by installation of strong electron-withdrawing groups on the para-positions of 1,7-phenyls and electron-donating groups on the para-positions of 3,4-phenyls. These dyes show strong NIR fluorescence emissions up to 756 nm, and absorptions up to 720 nm.

Conformationally restricted aza-dipyrromethene boron difluorides (aza-BODIPYs) with high fluorescent quantum yields.

A simple approach to the highly fluorescent near-infrared aza-BODIPY dyes with higher fluorescence quantum yields (up to 0.81 in toluene) in comparison with their known analogues is presented. Our approach is based on the restricted rotations of the 1,7-phenyl groups to the mean plane of the aza-BODIPYs, which is achieved through the installation of bulky substituents on the 1,7-phenyl groups of aza-BODIPYs and results in a reduced nonradiative relaxation process in solution.

β-Thiophene-fused BF2-azadipyrromethenes as near-infrared dyes.

A facile synthetic route to a new class of near-IR β-thiophene-fused BF2-azadipyrromethenes (aza-BDTPs) is presented. Sharp absorption and fluorescence emission bands at around 800 nm were observed for these highly photostable aza-BDTPs, with a large absorption coefficient and very low absorptions in the visible range from 700 to 380 nm.