Currently, there is an inherent contradiction between the multifunctionality and excellent biocompatibility of anticancer drug nanocarriers, which limits their application. Therefore, to overcome this limitation, we aimed to develop a biocompatible drug delivery system for the treatment of hepatocellular carcinoma (HCC). In this study, we employed poly(3-hydroxybutyrate--3-hydroxyvalerate) (PHBV) as the fundamental framework of the nanocarrier and utilized the emulsion solvent evaporation method to fabricate nanoparticles loaded with paclitaxel (PTX), known as PTX-PHBV NPs.
View Article and Find Full Text PDFleaves originate from the dry leaves of the plant. Flavonoids are the main functional components of leaves. Some flavonoids such as rutin, kaempferol and quercetin are rich in , and they have outstanding antioxidant efficacy.
View Article and Find Full Text PDFObjective: To investigate the effects of a microfluidic sperm sorter on the routine parameters and DNA integrity of human sperm.
Methods: We divided 40 semen samples into two aliquots and performed sperm sorting using a self-made polydimethylsiloxane microfluidic sperm sorter and the swim-up method, respectively. Then we evaluated and compared the effects of these two methods on the sperm routine parameters and DNA integrity by computer-assisted sperm analysis and sperm chromatin dispersion test.