Publications by authors named "Yaya Goita"
Article Synopsis
- The study aimed to evaluate how genetic variations (polymorphisms) in CYP2B6 and CYP3A4 affect the health responses of HIV-positive patients, focusing on their viral load and immune system functioning.
- A total of 153 patients were involved, and assessments were made on their viral loads and CD4 T cell counts at the start and after six months, utilizing TaqMan genotyping assays to identify genetic markers.
- Results indicated that certain genetic variations, particularly in CYP2B6, correlate with viral load suppression and increases in CD4 cell counts, suggesting these genetic markers could help predict treatment outcomes in HIV patients.
[Monitoring of glycemic balance by glycated hemoglobin assay on D-10® (Biorad) and Minicap Flex Piercing® (Sebia) biochemical systems at the Rodolph-Mérieux Laboratory in Bamako].
Ann Biol Clin (Paris)
June 2022
This study aims to determine the concordance of results between D-10® and Minicap Flex Piercing® and the impact of the presence of hemoglobin variants in the glycated hemoglobin assay. All the samples were assayed in parallel. The agreement between these methods was assessed using the Bland and Altman plot.
View Article and Find Full Text PDFMetabolomic studies have demonstrated the existence of biological signatures in blood of patients with arterial hypertension, but no study has hitherto reported the sexual dimorphism of these signatures. We compared the plasma metabolomic profiles of 28 individuals (13 women and 15 men) with essential arterial hypertension with those of a healthy control group (18 women and 18 men), using targeted metabolomics. Among the 188 metabolites explored, 152 were accurately measured.
View Article and Find Full Text PDFThe metabolomic profile of vaso-occlusive crisis, compared to the basal state of sickle cell disease, has never been reported to our knowledge. Using a standardized targeted metabolomic approach, performed on plasma and erythrocyte fractions, we compared these two states of the disease in the same group of 40 patients. Among the 188 metabolites analyzed, 153 were accurately measured in plasma and 143 in red blood cells.
View Article and Find Full Text PDFIntroduction: Arterial hypertension is a major public health problem in sub-Saharan Africa due to its high frequency and to the cardiovascular risk that it entails. The purpose of this study was to assess the prevalence of clinical and biological risk factors of hypertension in Bamako (Mali).
Methods: We conducted a case-control study, stratified in function of the sex, of 72 participants including 36 patients with hypertension and 36 controls.