Exosomal linc00152 intensifies the crosstalk between cholangiocarcinoma cells and cancer-associated fibroblasts.

Introduction And Objectives: Cholangiocarcinoma is a highly lethal carcinoma. Exosomes derived from cancer-associated fibroblasts (CAFs) serve key roles in the crosstalk between CAFs and cancer cells. Exploring the roles of CAF-derived exosomes and the mechanisms contribute to a better understanding of the development of cholangiocarcinoma.

Research on geological hazard characteristics and susceptibility of the Duku Highway based on SBAS-InSAR and improved spatiotemporal clustering.

The high-altitude Duku Highway is characterized by complex terrain changes and frequent geological hazards, which severely impact the lives of local residents and the sustainable development of the regional economy. The lack of understanding of terrain deformation, coupled with scarce foundational observation data, makes it challenging to apply mainstream susceptibility assessment methods such as slope modeling and causality analysis. Consequently, this study utilizes Sentinel-1 A data and employs the SBAS-InSAR technique to extract and analyze the deformation characteristics of 184 hazard areas along the Duku Highway over nearly three years.

Analysis and prediction of vegetation dynamics under the background of climate change in Xinjiang, China.

Background: Vegetation dynamics is defined as a significant indictor in regulating terrestrial carbon balance and climate change, and this issue is important for the evaluation of climate change. Though much work has been done concerning the correlations among vegetation dynamics, precipitation and temperature, the related questions about relationships between vegetation dynamics and other climatic factors (e.g.

Monitoring land surface thermal environments under the background of landscape patterns in arid regions: A case study in Aksu river basin.

Land surface temperature (LST) is defined as an important indicator in the formation and evolution of climate. In some cases, changes in landscape patterns affect LST, even more than the contribution of greenhouse gases. Although much work has been done with respect to the correlations between urban development and thermal environment dynamics, the related questions regarding relationships between LST and landscape patterns in arid regions are not thoroughly considered.

lncRNA CCAT1 is a biomarker for the proliferation and drug resistance of esophageal cancer via the miR-143/PLK1/BUBR1 axis.

Recent evidence indicates that long noncoding RNA colon cancer-associated transcript-1 (lncRNA CCAT1) is abundantly expressed in esophageal cancer and is closely related to the occurrence, development, invasion, metastasis, and drug resistance of this disease. However, the role and molecular mechanisms of CCAT1 in the cell proliferation and chemoresistance of esophageal cancer are largely unknown. The correlation between CCAT1 expression and drug resistance to cisplatin (CDDP) in esophageal squamous cell carcinoma (ESCC) cells was analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and quantitative real-time polymerase chain reaction (qRT-PCR) assays.