Redox-neutral decarboxylative coupling of fluoroalkyl carboxylic acids dual metal photoelectrocatalysis.

Given the importance and beneficial characteristics of aliphatic CF chiral compounds in modern chemistry, efficient strategies for their synthesis are highly sought after. While α-CF carboxylic acid is an emerging and easily accessible CF-containing synthon, its use as a source of fluoroalkyl is highly challenging due to its high oxidation potential. Herein, we disclose a photoelectrocatalytic method for the direct and enantioselective decarboxylative cross-coupling of α-CF carboxylic acids.

Direct electrophilic and radical isoperfluoropropylation with i-CF-Iodine(III) reagent (PFPI reagent).

The isoperfluoropropyl group (i-CF) is an emerging motif in pharmaceuticals, agrichemicals and functional materials. However, isoperfluoropropylated compounds remain largely underexplored, presumably due to the lack of efficient access to these compounds. Herein, we disclose the practical and efficient isoperfluoropropylation of aromatic C-H bonds through the invention of a hypervalent-iodine-based reagent-PFPI reagent, that proceeds via a Ag-X coupling process.

Monocyte at diagnosis as a prognosis biomarker in tuberculosis patients with anemia.

Background: Anemia leads to a lower cure rate and poor prognosis in tuberculosis patients. Effective predictors for the prognosis of tuberculosis with anemia (A-TB) are urgently needed. Monocyte has been proven to be a prognostic biomarker of many lung diseases.

Situation Element Extraction Based on Fuzzy Rough Set and Combination Classifier.

Generalized network security situation awareness technology is divided into three processes: situation element extraction, situation understanding, and situation prediction. Situation element extraction is the most critical step in the whole process, and its extraction quality will directly affect the accuracy of situation understanding and prediction. In view of the shortcomings of current situation element extraction methods, this study makes an in-depth study on the network security situation element extraction algorithm and proposes a situation element extraction model based on the fuzzy rough set and combined classifier, which is used to improve the accuracy of situation elements acquisition, so as to provide a better data basis for situation understanding and prediction.

Impact of anemia on prognosis in tuberculosis patients.

Background: Anemia is one of the risk factors for tuberculosis (TB), and more than 90% of TB patients suffer from anemia. The majority tuberculosis patients who had poor prognosis experienced anemia during the course of treatment. The objective of our study is to analyse the influences of anemia on the prognosis of tuberculosis patients in terms of pulmonary M.

Two new species of (, ) from southern China based on morphology and DNA sequence data.

Two new wood-inhabiting fungal species, and spp. nov., are proposed based on a combination of morphological features and molecular evidence.

Solid Phase Deposition Pattern Concerning Formation Oil in YD 7 Reservoir of Tarim Oilfield and Its Application: A Case Study.

Yudong (YD) 7 reservoir in the Yingmaili area of Tarim Oilfield is one of the key areas of oil and gas exploration in the Tarim Basin. However, due to the serious plugging problem caused by solid phase precipitation particles such as wax and paraffin, it is necessary to study the well flow phase behavior and solid phase precipitation law of typical high-production wells in this block to obtain the phase enveloping line and provide theoretical support for preventing solid phase precipitation of formation crude oil. In this study, the PVT tester and the self-designed microscopic solid deposition tester are used to obtain the phase enveloping line of formation crude oil, and the change law of the "gas-liquid-solid" phase behavior when the formation crude oil changes with temperature and pressure is observed.

Triclinic boron nanosheets high-efficient electrocatalysts for water splitting.

Recently, two-dimensional (2D) boron nanosheets have been predicted to exhibit exceptional physical and chemical properties, which is expected to be widely used in advanced electronics, optoelectronic, energy storage and conversion devices. However, the experimental application of 2D boron nanosheets in hydrogen evolution reactiuon (HER) has not been reported. Here, we have grown ultrathin boron nanosheets on tungsten foils via chemical vapor deposition.

rs12537 Is a Novel Susceptibility SNP Associated With Estrogen Receptor Positive Breast Cancer in Chinese Han Population.

Genetic testing is widely used in breast cancer and has identified a lot of susceptibility genes and single nucleotide polymorphisms (SNPs). However, for many SNPs, evidence of an association with breast cancer is weak, underlying risk estimates are imprecise, and reliable subtype-specific risk estimates are not in place. A recent genome-wide long non-coding RNA (lncRNA) association study in Chinese Han has verified a genetic association between rs12537 and breast cancer.

Steccherinum tenuissimum and S. xanthum spp. nov. (Polyporales, Basidiomycota): New species from China.

Two new wood-inhabiting fungal species, Steccherinum tenuissimum and S. xanthum spp. nov.

Loss-of-function variants in FSIP1 identified by targeted sequencing are associated with one particular subtype of mucosal melanoma.

Background: Mucosal melanoma is a tumor caused by the malignant transformation of pigment-producing cells and can arise from any mucosal tissue where melanocytes are present. Due to its rarity, the mucosal melanoma subtype is poorly described, and its genetic characteristics are infrequently studied. The discovery or confirmation of new mucosal melanoma susceptibility genes will provide important insights for the study of its pathogenesis.

Halogen substitution regulates the phase transition temperature and band gap of semiconductor compounds.

(CHCHNH)BiX and (CHClCHNH)BiX (X = Cl, Br) obtained by halogen substitution not only realize the adjustment of the phase transition in a relatively wide temperature range, but also optimize the semiconductor performance. This will promote the exploration and construction of semiconductor materials with tunable temperatures and lower band gaps.

High-throughput reformatting of phage-displayed antibody fragments to IgGs by one-step emulsion PCR.

Single-chain variable fragment (scFv) is the most common format for phage display antibody library. The isolated scFvs need to be reformatted to full-length IgGs for further characterization. High throughput reformatting of scFv to IgG without disrupting VH-VL pairing is of great demanding for exhaustive screening of all antibodies in IgG format.

Identification of novel Kv1.3 targeting venom peptides by a single round of autocrine-based selection.

Venom peptides are an excellent source of pharmacologically active molecules for ion channels that have been considered as promising drug targets. However, mining venoms that interact with ion channel remains challenging. Previously an autocrine based high throughput selection system was developed to screen venom peptide library but the method includes repetitious selection rounds that may cause loss of valuable hits.