Publications by authors named "Yaxing Shi"

Ubiquitin-specific peptidase 15 (USP15), a critical deubiquitinating enzyme, has been demonstrated to improve substrate stabilization by hydrolyzing the bond between the substrate and ubiquitin, and is implicated in multiple carcinogenic processes. Prompted by the information cited from The Cancer Genome Atlas (TCGA) database and the Cancer Proteogenomic Data Analysis Site (cProSite), USP15 is selectively overexpressed in clear cell renal cell carcinoma (ccRCC) samples. We aimed to investigate the function of USP15 on ccRCC malignant features, which was emphasized in its deubiquitination of SHC adaptor protein 1 (SHC1).

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Immune checkpoint genes (ICGs), which are the cornerstone of immunotherapy, influence the incidence and progression of clear cell renal cell carcinoma (ccRCC). It is important to note that there is not much data in the literature to determine how cuproptosis and antitumor immunity are related. On the basis of The Cancer Genome Atlas ccRCC dataset (n=526), cuproptosis-related ICGs (CICGs) were used to identify distinct molecular subtypes.

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Vegetable oil is an important part of the human diet and has multiple industrial uses. The rapid increase in vegetable oil consumption has necessitated the development of viable methods for optimizing the oil content of plants. The key genes regulating the biosynthesis of maize grain oil remain mostly uncharacterized.

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Background: Ferroptosis is a new type of iron- and reactive oxygen species-dependent cell death, studies on ferroptosis-related long noncoding RNAs (FerLncRNAs) in clear cell renal cell carcinoma (ccRCC) are limited. The purpose of this study was to investigate the potential prognostic value of FerLncRNAs and their relationship with the immune microenvironment and immunotherapy response of ccRCC.

Methods: RNA sequencing data of 526 patients with ccRCC were downloaded from The Cancer Genome Atlas (TCGA) database.

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The novel ZmR1 allele for maize anthocyanin synthesis was identified, and the biological function and regulatory molecular mechanisms of three ZmR1 alleles were unveiled. Anthocyanins in maize are valuable to human health. The R1 gene family is one of the important regulatory genes for the tissue-specific distribution of anthocyanins.

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Article Synopsis
  • Bladder cancer (BLCA) often spreads due to a process known as epithelial to mesenchymal transition (EMT), making it challenging to treat, and this study aims to find new genes that can act as prognostic biomarkers and treatment targets.
  • The researchers analyzed gene expression differences between normal and tumor samples using R programming tools, evaluated their prognostic value, and constructed a risk score model based on clinical characteristics.
  • They also studied the role of TEAD4 in regulating EMT and BLCA cell behavior through various laboratory assays to understand its effects on cancer progression and cell proliferation.
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Article Synopsis
  • Prostate cancer (PCa) cases are increasing, and the role of lncRNA SNHG3 in PCa needs more research despite its known effects on other cancers.
  • A study found high SNHG3 levels in PCa tissue and identified a regulatory axis involving SNHG3, miR-152-3p, and SLC7A11, supported by multiple assays confirming their interactions.
  • Results showed that SNHG3 promotes PCa cell growth and invasiveness while decreasing methionine dependence and apoptosis, and in animal models, reducing SNHG3 levels led to decreased tumor growth, highlighting its potential as a target for new PCa therapies.
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Circular RNA (circRNA) is a long non‑coding RNA molecule with a closed loop structure lacking a 5'cap and 3'tail. circRNA is stable, difficult to cleave and resistant to RNA exonuclease or RNase R degradation. circRNA molecules have several clinical applications, especially in tumors.

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Waxy maize has many excellent characteristics in terms of its nutritional and economic value. In recent decades, the waxy maize germplasm has increased dramatically as a result of different selection methods. We collected 200 waxy maize inbred accessions from different origins to study their genetic diversity and phylogenetic relationships, and to identify new waxy mutations.

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In recent years, autophagy has become a research hotspot in the field of pancreatic adenocarcinoma (PAAD) due to its ambiguous roles in pancreatic tumor progression. Hence, it is necessary to assess its clinical significance in a larger cohort of patients with PAAD. Here, we identified autophagy-related genes with prognostic value in PAAD and constructed a risk model based on these genes.

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To explore the effects of different types of forest environments for forest therapy, this study focused on forest resting environments. Seven representative forest resting environments found in field research in Beijing were used as independent variables and were shown to subjects by a virtual reality (VR) video. Stress level was used as the dependent variable, and blood pressure, heart rate, salivary amylase, and the Brief Profile of Mood States (BPOMS) were used as physiological and psychological indicators.

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The concentration, sources and environmental risks of polycyclic aromatic hydrocarbons (PAHs) in surface water in urban areas of Nanjing were investigated. The range of ∑PAHs concentration is between 4,076 and 29,455 ng/L, with a mean of 17,212 ng/L. The composition of PAHs indicated that 2- and 3-ring PAHs have the highest proportion in all PAHs, while the 5- and 6-ring PAHs were the least in proportion.

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Environmental pollution by heavy metals resulting from rapid economic development is a major concern. Soil, water, wheat, and rice samples were collected from the Lihe River Watershed in the Taihu Region (east China). In this study area, many types of industrial plants, including ceramics factories, plants working with refractory materials, and chemical plants are densely distributed and cause serious heavy metal pollution.

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Soil-crop system is an important way that heavy metals harm the ecological environment and human health. To research and understand the process of heavy metal absorption, migration and accumulation in soil-crop system is important for the prevention and control of heavy metal pollution and the health of human beings. In this paper, we established a model for crop uptake of heavy metals to calculate the heavy metals contents of wheat roots, stems, leaves and grains, and we analyzed the accumulation process of heavy metals in roots, stems, leaves and grains in the growth cycle of wheat.

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The assessment of critical loads of metals in soil can be used as an important tool for evaluation and for risk precaution of future inputs of metal in order to avoid the occurrence of heavy metal pollution and its long-term risks for people. In this study, critical loads of Cd, Cu, and Pb in farming and non-farming areas of Kunshan were calculated based on three main effects. Two of these effects, limit value of daily metals dose and different environmental water quality criteria are new ways to calculate the critical content of heavy metals.

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The globalization of agricultural trade has dramatically altered global nitrogen flows by changing the spatial pattern of nitrogen utilization and emissions at a global scale. As a major trading country, China uses a large amount of nitrogen, which has a profound impact on global nitrogen flows. Using data on food production and trade between China and 26 other countries and regions, we calculated nitrogen inputs and outputs in food production ecosystem in each country.

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China's rapid development of industrialization and urbanization causes the growing problem of heavy metal pollution of soil, threatening environment and human health. Therefore, prevention and management of heavy metal pollution become particularly important. Critical loads of heavy metals are an important management tool that can be utilized to prevent the occurrence of heavy metal pollution.

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Polycyclic aromatic hydrocarbons (PAHs) have become a major type of pollutant in urban areas and their degree of pollution and characteristics of spatial distribution differ between various regions. We conducted a comprehensive study about the concentration, source, spatial distribution, and health risk of 16 PAHs from urban to rural soils in Nanjing. The mean total concentrations of 16 PAHs (∑16PAHs) were 3330 ng g(-1) for urban soils, 1680 ng g(-1) for suburban soils, and 1060 ng g(-1) for rural soils.

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Waterlogging frequently occurs in Southern China in summer and significantly affects waxy maize growth. This study investigated the physicochemical properties of starch from six waxy maize varieties exposed to waterlogging for 1-7 days after pollination. Waterlogging decreased the starch granule size.

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