Identification of the key targets for sepsis-associated acute kidney injury by RNA sequencing combined with bioinformatics methods.

Purpose: This research probes into genes related to the risk of concurrent kidney injury in septic patients to provide reliable targets for early identification of sepsis-associated kidney injury and prognosis research.

Methods: Peripheral blood samples were isolated from 10 healthy individuals and 22 septic patients for RNA sequencing and differential analyses. Meanwhile, the top 1000 kidney-associated genes were chosen from the GTEx website.

Analyzing the molecular mechanism of Scutellaria Radix in the treatment of sepsis using RNA sequencing.

Background: Sepsis is a life-threatening organ dysfunction, which seriously threatens human health. The clinical and experimental results have confirmed that Traditional Chinese medicine (TCM), such as Scutellariae Radix, has anti-inflammatory effects. This provides a new idea for the treatment of sepsis.