Serum neurofilament light chain and inflammatory cytokines as biomarkers for early detection of mild cognitive impairment.

To investigate the association between serum neurofilament light chain (NfL) levels, inflammatory cytokines, and cognitive function to assess their utility in the early detection of mild cognitive impairment (MCI). We conducted a cross-sectional study involving 157 community-dwelling individuals aged 55 years and above, categorized into healthy controls, MCI, and probable Alzheimer's disease (AD). Serum levels of NfL, inflammatory cytokines, and AD pathology markers were measured using enzyme-linked immunosorbent assay (ELISA).

The diagnostic value of cognitive assessment indicators for mild cognitive impairment (MCI).

Objective: This study aims to evaluate and analyze the standard diagnostic methods for mild cognitive impairment (MCI).

Methods: This study used a prospective case-control study to examine baseline data and diagnostic indicators in a population of elderly with MCI. Based on different cognitive abilities, this study divided MCI and healthy control groups.