Publications by authors named "Yaxin Guo"

The effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection persist months and years after recovery. We conducted an online survey to assess the health condition of convalescents approximately 5 months following the primary infection of SARS-CoV-2. The study recruited 5,510 individuals who were primary infected, 626 participants who had experienced reinfection, and 521 participants who were without infective history.

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Objective: To evaluate the pregnancy and perinatal outcomes of different phenotypes of polycystic ovary syndrome (PCOS) patients during the frozen embryo transfer (FET) cycles. Additionally, to analyze the T cell balance in the endometrium of PCOS patients and explore its relationship with various PCOS phenotypes.

Design: Retrospective cohort study.

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Artificial nanofluidic devices inspired bylight-driven ion transport in biological systems, leveraging the photoelectric effect, have attracted extensive attention for their potential in signal transduction and smart ion transport applications. However, effective separation of photogenerated carriers in traditional p-n junction interface can be hindered by energy band structure of different semiconductor materials. Here, we present a novel approach using conductive polypyrrole (PPy) to modify graphene oxide (GO), creating polypyrrole-graphene oxide (PyGO) functional lamellar conductive nanochannels with tailored channel-sized gradients and inherent optical-electrical coupling sensitivity via a facile super-assembly strategy.

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A huge challenge is how to prepare flexible silicone aerogel materials with good flame retardancy, thermal stability, and hydrophobic properties. In this paper, resorcinol-formaldehyde was introduced into the silicone network composed of methyltrimethoxysilane (MTMS), phenyltriethoxysilane (PTES), and dimethyldimethoxysilane (DMDMS). Flexible hybrid aerogels with excellent thermal insulation, flame retardant, and hydrophobic properties were prepared by the sol-gel method and ambient pressure drying (APD), and the preparation process does not require long-term solvent exchange, only about 3 h of soaking and washing of the wet gel.

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Achieving targeted hypermutation of specific genomic sequences without affecting other regions remains a key challenge in continuous evolution. To address this, we evolved a T7 RNA polymerase (RNAP) mutant that synthesizes single-stranded DNA (ssDNA) instead of RNA in vivo, while still exclusively recognizing the T7 promoter. By increasing the error rate of the T7 RNAP mutant, it generates mutated ssDNA that recombines with homologous sequences in the genome, leading to targeted genomic hypermutation.

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Although antibody escape is observed in emerging severe acute respiratory syndrome coronavirus 2 variants, T cell escape, especially after the global circulation of BA.2.86/JN.

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Background: Histological grade is an acknowledged prognostic factor for breast cancer, essential for determining clinical treatment strategies and prognosis assessment. Our study aims to establish intra- and peritumoral radiomics models using T2WI and DWI MR sequences for predicting the histological grade of breast cancer.

Methods: 700 breast cancer cases who had MRI scans before surgery were included.

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Background: Core biopsy sampling may not fully capture tumor heterogeneity. Radiomics provides a non-invasive method to assess tumor characteristics, including both the core and surrounding tissue, with the potential to improve the accuracy of HER-2 status prediction.

Objective: To explore the clinical value of intratumoral and peritumoral radiomics features from dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for preoperative prediction of human epidermal growth factor receptor-2 (HER-2) expression status in breast cancer.

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Hydrogen is an essential energy resource, playing a pivotal role in advancing a sustainable future. Electrolysis of seawater shows great potential for large-scale hydrogen production but encounters challenges such as electrode corrosion caused by chlorine evolution. Herein, a durable CoCO/CoFe layered double hydroxide (LDH) electrocatalyst is presented for alkaline seawater oxidation, showcasing resistance to corrosion and stable operation exceeding 1,000 h at a high current density of 1 A cm.

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Objective: To establish and validate a new clinical-radiomics nomogram based on the fat-suppressed T2 sequence for differentiating luminal and non-luminal breast cancer.

Methods: A total of 593 breast cancer patients who underwent preoperative breast MRI from Jan 2017 to Dec 2020 were enrolled, which were randomly divided into the training (n=474) and test sets (n=119) at the ratio of 8:2. Intratumoral region (ITR) of interest were manually delineated, and peritumoral regions of 3 mm and 5 mm (PTR-3 mm and PTR-5 mm) were automatically obtained by dilating the ITR.

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Article Synopsis
  • * Researchers conducted various experiments (in vitro and in vivo) showing that circAURKA promotes the proliferation and metastasis of CRC cells.
  • * Mechanistically, circAURKA increases the stability of the CTNNB1 protein by reducing its degradation, influencing CRC progression, and suggesting potential targeted therapeutic approaches.
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Directed evolution seeks to evolve target genes at a rate far exceeding the natural mutation rate, thereby endowing cellular and enzymatic properties with desired traits. In vivo continuous directed evolution achieves these purposes by generating libraries within living cells, enabling a continuous cycle of mutant generation and selection, enhancing the exploration of gene variants. Continuous evolution has become powerful tools for unraveling evolution mechanism and improving cellular and enzymatic properties.

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Article Synopsis
  • This study investigates the role of circular RNAs (circRNAs) in colorectal cancer (CRC), specifically focusing on how abnormal expression of circRNAs might be linked to m7G RNA modifications.* -
  • Researchers found that METTL1 catalyzes these m7G modifications, which prevent degradation of a specific circRNA, circKDM1A, known to promote cancer cell growth and spread.* -
  • The study highlights that m7G-modified circKDM1A activates the AKT signaling pathway by increasing PDK1 levels, thereby advancing CRC progression and establishing METTL1's critical role in cancer biology.*
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Article Synopsis
  • Adolescent alcohol exposure is linked to cognitive issues in adulthood, particularly affecting spatial learning and memory, partly due to neural damage in critical brain areas like the mPFC, NAc, and HIP.
  • The integrated stress response (ISR) plays a key role in learning and memory, but its effects after alcohol exposure during adolescence are not well understood.
  • Using an ISR inhibitor (ISRIB) improved memory deficits and neuronal damage linked to alcohol exposure, suggesting it may help restore brain function affected by early alcohol use.
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Developing an activity detection platform for hyaluronidase (HAase) is crucial for diagnosing and treating cancer. However, traditional detection of HAase is based on changes in the flow rate caused by viscosity or requires complex modifications and processing, which limits the detection accuracy and sensitivity. Herein, hyaluronic acid (HA)-modified mesoporous-based heterochannels (mesoporous carbon-doped γ-FeO nanoparticles/anodized aluminum oxide, MC-γ-FeO/AAO) featuring ordered 3D transport frameworks and a photothermal property were developed for high performance HAase detection.

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TFE3 and TFEB, as the master regulators of lysosome biogenesis and autophagy, are well characterized to enhance the synaptic protein α-synuclein degradation in protecting against Parkinson's disease (PD) and their levels are significantly decreased in the brain of PD patients. However, how TFE3 and TFEB are regulated during PD pathogenesis remains largely vague. Herein, we identified that programmed cell death 4 (PDCD4) promoted pathologic α-synuclein accumulation to facilitate PD development via suppressing both TFE3 and TFEB translation.

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Short-chain fatty acids (SCFAs) have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via the microbiota-gut-brain axis. However, the precise mechanism by which brain SCFAs extert multiple beneficial effects is not completely understood. Our previous research has demonstrated that the acetyl-coenzyme A synthetase short-chain family member 2 (ACSS2) is a novel target of the rapid and long-lasting antidepressant responses.

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Tuberous sclerosis complex 2 (TSC2) crucially suppresses Rheb activity to prevent mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation, thereby causing various developmental disorders and cancer. Therefore, the discovery of novel Rheb inhibitors is vital to prevent mTOR overactivation.

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The individual HLA-related susceptibility to emerging viral diseases such as COVID-19 underscores the importance of understanding how HLA polymorphism influences peptide presentation and T cell recognition. Similar to HLA-A*0101, which is one of the earliest identified HLA alleles among the human population, HLA-A*2601 possesses a similar characteristic for the binding peptide and acts as a prevalent allomorph in HLA-I. In this study, we found that, compared with HLA-A*0101, HLA-A*2601 individuals exhibit distinctive features for the T cell responses to SARS-CoV-2 and influenza virus after infection and/or vaccination.

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As one of the most effective measures to prevent seasonal influenza viruses, annual influenza vaccination is globally recommended. Nevertheless, evidence regarding the impact of repeated vaccination to contemporary and future influenza has been inconclusive. A total of 100 subjects singly or repeatedly immunized with influenza vaccines including 3C.

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Background: Peripheral FDG accumulation in a hepatic hemangioma presenting in a patient with prolonged fever is rare. Therefore, clinicians should pay close attention to patients with hepatic mass.

Case Summary: A 54-year-old woman with a 4-wk history of daily fevers was admitted to our hospital.

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Bioinspired nanochannel-based sensors have elicited significant interest because of their excellent sensing performance, and robust mechanical and tunable chemical properties. However, the existing designs face limitations due to material constraints, which hamper broader application possibilities. Herein, a heteromembrane system composed of a periodic mesoporous organosilica (PMO) layer with three-dimensional (3D) network nanochannels is constructed for glutathione (GSH) detection.

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Polybrominated diphenyl ethers (PBDEs), widely used as flame retardants, easily enter the environment, thus posing environmental and health risks. Iron materials play a key role during the migration and transformation of PBDEs. This article reviews the processes and mechanisms of adsorption, degradation, and biological uptake and transformation of PBDEs affected by iron materials in the environment.

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Background: Psoriasis is a prevalent chronic inflammatory dermatosis characterized by the excessive proliferation of keratinocytes (KCs). Lysine 2-hydroxyisobutyrylation (Khib) is a newly identified post-translational modification that regulates various biological processes. Abnormal Khib modification has been associated with the development of autoimmune diseases.

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Objective: To investigate the value of predicting axillary lymph node (ALN) metastasis based on intratumoral and peritumoral dynamic contrast-enhanced MRI (DCE-MRI) radiomics and clinico-radiological characteristics in breast cancer.

Methods: A total of 473 breast cancer patients who underwent preoperative DCE-MRI from Jan 2017 to Dec 2020 were enrolled. These patients were randomly divided into training (n=378) and testing sets (n=95) at 8:2 ratio.

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