Publications by authors named "Yawen Hu"

Clinical and experimental evidence indicates that alcohol use causes various abnormalities in the immune system and compromises immune functions. However, the mechanistic understanding of ethanol's effects on the immune system remains limited. Cyclic AMP (cAMP) regulates multiple processes, including immune responses.

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The skin serves as the first protective barrier for nonspecific immunity and encompasses a vast network of skin-associated immune cells. Atopic dermatitis (AD) is a prevalent inflammatory skin disease that affects individuals of all ages and races, with a complex pathogenesis intricately linked to genetic, environmental factors, skin barrier dysfunction as well as immune dysfunction. Individuals diagnosed with AD frequently exhibit genetic predispositions, characterized by mutations that impact the structural integrity of the skin barrier.

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Background & Aims: Cystic fibrosis (CF) is an autosomal recessive genetic disorder, affecting multiple organ systems. CF intestinal disease develops early, manifesting as intestinal bacterial overgrowth/dysbiosis, neutrophilic inflammation, and obstruction. As unresolvable infection and inflammation reflect host immune deficiency, we sought to determine if the CF-affected immune system plays any significant role in CF intestinal disease pathogenesis.

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Psoriatic arthritis (PsA) is an immune-mediated, chronic inflammatory joint disease that commonly occurs as a complication of psoriasis. EGF-like repeats and discoidal I-like domain 3 (EDIL3) is a secreted protein with multiple structural domains and associated with various physiological functions. In this study, we employed a mannan-induced psoriatic arthritis model to investigate the impact of EDIL3 on PsA pathogenesis.

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Article Synopsis
  • The study achieved successful purification of lincomycin using macroporous adsorption resin column chromatography with HZ3 resin.
  • Optimal parameters included a 33 cm column bed height, 48 mg/mL sample loading capacity, and a 1 mL/min flow rate for loading.
  • The resulting lincomycin purity was 99.00% with a yield of 97.84%, making the method efficient and promising for pharmaceutical applications.
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  • - Atopic dermatitis (AD) is a skin condition characterized by inflammation, with interleukin-38 (IL-38) playing a complex and unclear role in its development; it’s mostly produced by skin cells called keratinocytes and is found at lower levels in AD-affected skin.
  • - Researchers created special mice lacking IL-38 in their skin cells, and when these mice were exposed to a chemical that induces AD, they experienced less skin inflammation, suggesting that IL-38 contributes to the condition by influencing immune cell behavior.
  • - The study found that IL-38 promotes the movement of Langerhans cells (a type of immune cell) to lymph nodes, which is key in AD progression, but this
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Caffeic acid phenethyl ester (CAPE) is a naturally occurring phenolic compound with various biological activities. However, poor water solubility and storage stability limit its application. In this context, sorghum peptides were used to encapsulate CAPE.

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  • Human cystic echinococcosis (CE) is a serious zoonotic disease, and its rare coexistence with hepatocellular carcinoma (HCC) and liver abscess is not previously documented.
  • A case involving a 65-year-old herdsman revealed the presence of jaundice, elevated alpha fetoprotein levels, and distinct lesions in the liver diagnosed as CE and HCC, along with a subsequent liver abscess.
  • This case emphasizes the importance of personalized treatment approaches and multidisciplinary discussions for managing complex interactions between CE, HCC, and liver abscess in patients.
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Herein, 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a model template in a rational design strategy to produce water-compatible noncovalent imprinted microspheres. The proposed approach involved computational modelling for screening functional monomers and a simple method for preparing monodisperse and highly cross-linked microspheres. The fabricated non-imprinted polymer (NIP) and 2,4-d-imprinted polymer (2,4-d-MIP) were characterised, and their adsorption capabilities in an aqueous environment were evaluated.

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An efficient asymmetric remote arylation of C(sp)-H bonds under photoredox conditions is described here. The reaction features the addition radicals to a double bond followed by a site-selective radical translocation (1,n-hydrogen atom transfer) as well as a stereocontrolled aryl migration via sulfinyl-Smiles rearrangement furnishing a wide range of chiral α-arylated amides with up to >99 : 1 er. Mechanistic studies indicate that the sulfinamide group governs the stereochemistry of the product with the aryl migration being the rate determining step preceded by a kinetically favored 1,n-HAT process.

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Designing a stable and highly active catalyst for hydrogen evolution and oxygen evolution reactions (HER/OER) is essential for the industrialization of hydrogen energy but remains a major challenge. This work reports a simple approach to fabricating coupled CoP/FeP nanorod array catalyst for overall water decomposition, demonstrating the source of excellent activity in the catalytic process. Under alkaline conditions, CoP/FeP heterostructures exhibit an overpotential of 96 and 220 mV for HER and OER, respectively, at 10 mA cm.

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Two- or one-electron-mediated difunctionalizations of internal alkenes represent straightforward approaches to assemble molecular complexity by the simultaneous formation of two contiguous Csp stereocentres. Although racemic versions have been extensively explored, asymmetric variants, especially those involving open-shell C-centred radical species, are much more limited both in number and scope. Here we describe enantioenriched arylsulfinylamides as all-in-one reagents for the efficient asymmetric, intermolecular aminoarylation of alkenes.

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  • Necrotrophic fungal pathogens like Sclerotinia sclerotiorum use specific proteins called cell death-inducing proteins (CDIPs) to promote their infection in plants, but the details of these proteins have not been well-studied.
  • Researchers discovered that S. sclerotiorum secretes a protein called SsXyl2, which triggers cell death in host plants during infection, independent of its enzymatic activity.
  • The study reveals that a plant protein (NbHIR2) interacts with SsXyl2 to enhance its effectiveness in causing cell death, and disruptions in this interaction can increase plant resistance, paving the way for developing more resistant crop varieties.
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Computer-Aided Diagnosis (CAD) for polyp detection offers one of the most notable showcases. By using deep learning technologies, the accuracy of polyp segmentation is surpassing human experts. In such CAD process, a critical step is concerned with segmenting colorectal polyps from colonoscopy images.

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Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the CF Transmembrane-conductance Regulator (CFTR) gene. The most severe pathologies of CF occur in the lung, manifesting as chronic bacterial infection, persistent neutrophilic inflammation, and mucopurulent airway obstruction. Despite increasing knowledge of the CF primary defect and the resulting clinical sequelae, the relationship between the CFTR loss of function and the neutrophilic inflammation remains incompletely understood.

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Cystic fibrosis is a life-shortening genetic disorder, caused by mutations in the gene that encodes cystic fibrosis transmembrane-conductance regulator, a cAMP-activated chloride and bicarbonate channel. Persistent neutrophilic inflammation is a major contributor to cystic fibrosis lung disease. However, how cystic fibrosis transmembrane-conductance regulator loss of function leads to excessive inflammation and its clinical sequela remains incompletely understood.

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Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved posttranslational modification in eukaryotes. GPI-anchored proteins are widely distributed in fungal plant pathogens, but the specific roles of the GPI-anchored proteins in the pathogenicity of Sclerotinia sclerotiorum, a devastating necrotrophic plant pathogen with a worldwide distribution, remain largely unknown. This research addresses , which encodes an glycine- and serine-rich protein named SsGsr1 with an N-terminal secretory signal and a C-terminal GPI-anchor signal.

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For transradial amputees, especially those with insufficient residual muscle activity, it is challenging to quickly obtain an appropriate grasping pattern for a multigrasp prosthesis. To address this problem, this study proposed a fingertip proximity sensor and a grasping pattern prediction method base on it. Rather than exclusively utilizing the EMG of the subject for the grasping pattern recognition, the proposed method used fingertip proximity sensing to predict the appropriate grasping pattern automatically.

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Cystic fibrosis is a life-threatening genetic disorder caused by mutations in the CFTR chloride channel. Clinically, over 90% of patients with cystic fibrosis succumb to pulmonary complications precipitated by chronic bacterial infections, predominantly by Pseudomonas aeruginosa and Staphylococcus aureus. Despite the well-characterized gene defect and clearly defined clinical sequelae of cystic fibrosis, the critical link between the chloride channel defect and the host defense failure against these specific pathogens has not been established.

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The environmental and ecological consequences of nanoplastics (NPs) draw increasing research interests and social concerns. However, the in situ and real-time detection of NPs from living organisms and transferring media remains as a major technical obstacle for scientific investigation. Herein we report a novel time-gated imaging (TGI) strategy capable of real-time visualizing the intake of NPs by an individual living organism, which is based on the polystyrene NPs labelled with lanthanide up-conversion luminescence.

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Objectives: To image knee osteochondral specimens using magnetic resonance (MR) ultrashort echo time imaging with pointwise encoding time reduction with radial acquisition combined fat suppression (PETRA-FS) sequence to determine whether it can reveal non-calcified cartilage, including the deep radial layer, and to assess its effectiveness in cartilage damage diagnosis.

Materials And Methods: PETRA-FS imaging was performed on 58 osteochondral specimens of the lower femur and upper tibia to observe depth of cartilage damage, combined with histological results to observe signal intensity composition. Sensitivity, specificity, and reliability of PETRA-FS sequence for diagnosing cartilage damage were evaluated using histological results as the gold standard.

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Interleukin 37 (IL-37), a member of the IL-1 family, is considered a suppressor of innate and adaptive immunity and, hence is a regulator of tumor immunity. However, the specific molecular mechanism and role of IL-37 in skin cancer remain unclear. Here, we report that IL-37b-transgenic mice (IL-37tg) treated with the carcinogenic 7,12-dimethylbenzoanthracene (DMBA)/12-o-tetradecylphorbol-13-acetate (TPA) exhibited enhanced skin cancer and increased tumor burden in the skin by inhibiting the function of CD103 dendritic cells (DCs).

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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczema-like skin lesions, dry skin, severe itching, and recurrent recurrence. The whey acidic protein four-disulfide core domain gene WFDC12 is highly expressed in skin tissue and up-regulated in the skin lesions of AD patients, but its role and relevant mechanism in AD pathogenesis have not been studied yet. In this study, we found that the expression of WFDC12 was closely related to clinical symptoms of AD and the severity of AD-like lesions induced by DNFB in transgenic mice.

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Efficient harvesting and storage of dispersed irregular energy from the environment are crucial to the demand for the distributed devices of the Internet of Things (IoTs). Here, a carbon felt (CF)-based energy conversion-storage-supply integrated system (CECIS) that contains a CF-based solid-state supercapacitor (CSSC) and a CF-based triboelectric nanogenerator (C-TENG) is presented, which is capable of simultaneously energy storage and conversion. The simple treated CF not only delivers a maximal specific capacitance of 402.

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Cystic fibrosis (CF) is a life-shortening genetic disorder, caused by mutations in the gene that encodes Cystic Fibrosis Transmembrane-conductance Regulator (CFTR), a cAMP-activated chloride and bicarbonate channel. Although multiple organ systems can be affected, CF lung disease claims the most morbidity and mortality due to chronic bacterial infection, persistent neutrophilic inflammation, and mucopurulent airway obstruction. Despite the clear predominance of neutrophils in these pathologies, how CFTR loss-of-function affects these cells remains incompletely understood.

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