Habitat preference drives the community composition, beta diversity and assembly processes of benthic diatoms: A case study of a wetland cluster in a cold region.

The loss of biodiversity in urban wetlands has become increasingly severe due to urbanization. Based on their attachment patterns, benthic diatoms can be divided into several types according to habitat (i.e.

A highly compressible and expandable cellulose sponge with arch-like lamellar structures for non-compressible hemorrhage.

The development of highly expandable sponges for non-compressible hemorrhage remains a challenge in both civilian and war scenarios. Herein, a cellulose-based highly expandable sponge with arch-like lamellar structure was prepared by introducing interlayer calcium ion cross-linking in the sponges obtained by bi-directional freezing. The cellulose sponge, which has an arched layered structure that can withstand large stress strain, is compressed into small sizes to enter narrow and deep bleeding points, and then expand about 11 times after liquid absorption to apply sufficient and constant pressure on the bleeding points.

Discovery of novel spirocyclic derivates as potent androgen receptor antagonists.

We report herein the development of a series of novel AR antagonists characterized by a spirocyclic scaffold, employing scaffold hopping and structure-based drug design strategies. Most of the spirocyclic derivatives exhibited enhanced AR antagonistic activity and superior antiproliferative activity against LNCaP cells compared to enzalutamide. Among them, compound 21 demonstrated moderate antiproliferative activity against enzalutamide resistant prostate cancer cell lines and exhibited favorable in vitro metabolic stability.

Molecular and morphological investigations of two new species in Qinia and Cymbella (Bacillariophyceae: Cymbellales) from China.

Molecular data is provided firstly for the newly erected genus Qinia, and the phylogenetic position of the genus Qinia within the Cymbellales is discussed. Despite the presence of apical pore fields bisected by the distal raphe fissure being a very distinctive feature for Qinia, molecular analysis demonstrates this character as homoplasious, having evolved independently in Qinia and Cymbella. Two new species, Qinia hubeii sp.

Towards a unified test for the intercept of autoregressive models.

It has long been an open problem to provide a unified test for the intercept of autoregressive (AR) models. In this paper, we use the empirical likelihood method to solve this issue. It turns out that the resulting test statistic always converges in distribution to a standard chi-squared distribution under the null hypothesis, whether the AR process is stationary or nonstationary, and with or without an intercept.

CrackNet: A Hybrid Model for Crack Segmentation with Dynamic Loss Function.

Cracks are a common form of damage in infrastructure, posing significant risks to both personal safety and property. Along with the development of deep learning, visual-based crack automatic detection has been widely studied. However, this task is still challenging due to complex crack topology, noisy backgrounds, unbalanced categories, etc.

Transcriptomic response analysis of ultraviolet mutagenesis combined with high carbon acclimation to promote photosynthetic carbon assimilation in .

The potential of for carbon sequestration offers significant opportunities in the capture and utilization of carbon dioxide (CO). In this study, a mutant LE-ZW of , capable of efficient growth and carbon sequestration, was obtained through ultraviolet mutagenesis combined with high carbon acclimation. Subsequently, the potential of LE-ZW for carbon assimilation was systematically analyzed.

Testing serial correlation in a general -factor model with possible infinite variance.

It is well-known that the presence of serial correlation may result in an inefficient or even biased estimation in time series analysis. In this paper, we consider testing serial correlation in a general -factor model when the model errors follow the GARCH process, which is frequently used in modeling financial data. Two empirical likelihood-based testing statistics are suggested as a way to deal with problems that might come up with infinite variance.

Overexpression of histone demethylase gene SlJMJ18 and SlJMJ23 from tomato confers cadmium tolerance by regulating metal transport and hormone content in Arabidopsis.

A lower concentration of cadmium (Cd), a hazardous and non-essential element for plant growth, will have deleterious effects on plants and endanger human health. Histone demethylase (JHDM) is important for plants' ability to withstand abiotic stress, according to an increasing number of studies. The degree of expression of the SlJMJ18 and SlJMJ23 genes in different tomato tissues was confirmed by this study.

Discovery of novel biphenyl derivatives as androgen receptor degraders for the treatment of enzalutamide-resistant prostate cancer.

Second-generation AR antagonists, such as enzalutamide, are the primary therapeutic agents for advanced prostate cancer. However, the development of both primary and secondary drug resistance leads to treatment failures and patient mortality. Bifunctional agents that simultaneously antagonize and degrade AR block the AR signaling pathway more completely and exhibit excellent antiproliferative activity against wild-type and drug-resistant prostate cancer cells.

Biomedical Applications of Sulfonylcalix[4]arene-Based Metal-Organic Supercontainers.

Coordination cages sustained by metal-ligand interactions feature polyhedral architectures and well-defined hollow structures, which have attracted significant attention in recent years due to a variety of structure-guided promising applications. Sulfonylcalix[4]arenes-based coordination cages, termed metal-organic supercontainers (MOSCs), that possess unique multi-pore architectures containing an cavity and multiple cavities, are emerging as a new family of coordination cages. The well-defined built-in multiple binding domains of MOSCs allow the efficient encapsulation of guest molecules, especially for drug delivery.

De novo transcriptome assembly and molecular response mechanism analysis of a diatom Cyclotella meneghiniana Kützing exposed to cadmium.

Cadmium is a persistent heavy metal commonly found in aquatic ecosystems and has a strong toxic effect on organisms. The sensitivity of phytoplankton to environmental changes and its role as an indicator of aquatic ecosystem health have been well-established. However, the mechanisms by which phytoplankton respond to cadmium remain incompletely understood.

Differential protein analysis of saline-alkali promoting the oil accumulation in Nitzschia palea.

Background: The increasingly severe salinization of the aquatic environment has led to serious damage to the habitats of aquatic organisms. Benthic diatoms are commonly employed as indicator species for assessing water quality and serve as a reflection of the overall health of the aquatic ecosystem. Nitzschia palea is a common diatom found in freshwater, with high oil content, rapid reproductive rate, and it is a commonly dominant species in various rivers.

A new species of genus (Bacillariophyta) from Tibet, China.

During the investigation of the freshwater diatoms from Tibet, a monoraphid species was observed from a hot spring near Anduo County, located on a plateau in the central portion of Tibet. This species shares the diagnostic features of , such as the valve bent along the transapical axis, striae uniseriate to biseriate from centre to the apices and areolae with special structures located at the end of each stria. We compared the morphological characters of this new species with the others in this genus and show it to be new; it is named This species has small valves with slightly protracted ends with nearly capitate apices, lanceolate axial area, central area unilaterally expanded to the margin, striae uniseriate to biseriate, but, in some valves, the striae are only uniseriate.

Multiple stressors determine the process of the benthic diatom community assembly and network stability in urban water bodies in Harbin.

Human activities have triggered biodiversity loss, often resulting in biotic homogenization, which poses a threat to human well-being. Nevertheless, the overall influence of diverse environmental stressors on intra- and inter-community diversity remains insufficiently elucidated. This study aimed to quantify and reveal the impact of environmental stressors on the alpha and beta diversities of benthic diatom communities in the Harbin urban river network during the summer and autumn of 2022 and spring of 2023.

Discovery of (2)--(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment.

Androgenetic alopecia (AGA) is the most prevalent form of progressive hair loss disorder in both men and women, significantly impacting their appearance and overall quality of life. Overactivation of the AR signaling pathway in dermal papilla cells (DPCs) plays a crucial role in the development and progression of AGA. Considering the severe systemic side effects associated with oral AR antagonists, the idea of developing of topical AR antagonists with rapid metabolic deactivation properties emerged as a promising approach.

Transcriptome analysis of the effects of different carbon dioxide concentrations on paramylon accumulation in Euglena gracilis Z.

Appropriate concentration of carbon dioxide (CO) will promote algae growth and metabolism. Building upon this finding, the present study investigated the impact of different CO concentrations (5% and 20%) on the carbon sequestration capacity of E. gracilis through aeration culturing, employing a combination of physiological analyses and transcriptome analysis.

Effectively Modulating Oxygen Vacancies in Flower-Like δ-MnO Nanostructures for Large Capacity and High-Rate Zinc-Ion Storage.

In recent years, manganese-based oxides as an advanced class of cathode materials for zinc-ion batteries (ZIBs) have attracted a great deal of attentions from numerous researchers. However, their slow reaction kinetics, limited active sites and poor electrical conductivity inevitably give rise to the severe performance degradation. To solve these problems, herein, we introduce abundant oxygen vacancies into the flower-like δ-MnO nanostructure and effectively modulate the vacancy defects to reach the optimal level (δ-MnO-2.

Changes in the gut microbiota structure and function in rats with doxorubicin-induced heart failure.

Objectives: The rat model of heart failure (HF) induced by doxorubicin (DOX), a broad spectrum and highly effective chemotherapeutic anthracycline with high-affinity to myocardial tissue that causes severe dose-dependent irreversible cardiotoxicity has been widely recognized and applied in HF pathogenesis and drug therapy studies. The gut microbiota (GM) has attracted significant attention due to its potential role in HF, and research in this area may provide beneficial therapeutic strategies for HF. Considering the differences in the route, mode, and total cumulative dose of DOX administration used to establish HF models, the optimal scheme for studying the correlation between GM and HF pathogenesis remains to be determined.

[Characteristics of Benthic Diatom Community Structure and Water Ecological Health Evaluation in the Lalin River Basin].

With the improvement of public requirements for the health status of aquatic ecosystems, there have been innovative assessment methods developed for aquatic ecosystems. In this study, benthic algae assemblages and water quality variables were analyzed to develop a benthic diatom-based index of biotic integrity (D-IBI) for the assessment of the aquatic environment in the Lalin River. In addition, using redundancy analysis (RDA) based on dominant species and physicochemical indexes, the ecological distribution characteristics of the benthic diatom community were revealed, and the key influencing factors were identified.

Elucidating Flavonoid and Antioxidant Activity in Edible and Medicinal Herbs (L.f.) Sm. Based on HPLC-ESI-TOF-MS and Artificial Neural Network Model: Response to Climatic Factors.

is a kind of great potential edible and medicinal fern. In a previous study, it was found that flavonoid and antioxidant activity of from different sites were different. However, the cause of the differences has still been unclear, which has restricted the utilization of .

Influence of biotin intervention on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

Background: Biotin is a water-soluble vitamin acting as a covalently bound coenzyme in regulating energy production. Previous studies have reported that biotin supplementation may influence blood glucose and lipid level in patients with type 2 diabetes mellitus (T2DM).

Methods: We searched Pubmed, Embase, and Cochrane library databases up to 8th August 2022 for studies examining the effects of biotin supplementation in T2DM patients.

Testing the Intercept of a Balanced Predictive Regression Model.

Testing predictability is known to be an important issue for the balanced predictive regression model. Some unified testing statistics of desirable properties have been proposed, though their validity depends on a predefined assumption regarding whether or not an intercept term nevertheless exists. In fact, most financial data have endogenous or heteroscedasticity structure, and the existing intercept term test does not perform well in these cases.