Polycationic Open-Shell Cyclophanes: Synthesis of Electron-Rich Chiral Macrocycles, and Redox-Dependent Electronic States.

π-Conjugated chiral nanorings with intriguing electronic structures and chiroptical properties have attracted considerable interests in synthetic chemistry and materials science. We present the design principles to access new chiral macrocycles (1 and 2) that are essentially built on the key components of main-group electron-donating carbazolyl moieties or the π-expanded aza[7]helicenes. Both macrocycles show the unique molecular conformations with a (quasi) figure-of-eight topology as a result of the conjugation patterns of 2,2',7,7'-spirobifluorenyl in 1 and triarylamine-coupled aza[7]helicene-based building blocks in 2.

sp. nov. and sp. nov., isolated from coastal sediment.

Two novel rod-shaped, Gram-stain-negative, aerobic and non-motile bacterial strains, designated M39 and C2-7, were isolated from the coastal sediment of Xiaoshi Island, Weihai, PR China. Growth of strain M39 occurred at 15-37 °C, at pH 6.0-9.

sp. nov. and sp. nov., two novel bacteria isolated from intertidal sediment.

Two novel Gram-stain-negative, facultative anaerobic, chemoheterotrophic, non-motile and rod-shaped strains were isolated from intertidal sediment sampled at Xiaoshi Island, Weihai, PR China. Full sequence analysis of the 16S rRNA genes showed that the two strains were closely related to members of the genus and the phylogenetic similarities to their closest relative, , were 96.7 and 95.

Design and Synthesis of New Type of Macrocyclic Architectures Used for Optoelectronic Materials and Supramolecular Chemistry.

Supramolecular chemistry has received much attention for decades. Macrocyclic architectures as representative receptors play a vital role in supramolecular chemistry and are applied in many fields such as supramolecular assembly and host-guest recognition. However, the classical macrocycles generally lack functional groups in the scaffolds, which limit their further applications, especially in optoelectronic materials.

Red Emissive Double Aza[7]helicenes with Antiaromaticity / Aromaticity Switching via the Redox-Induced Radical Cation and Dication Species.

We herein present the synthetic approach to a new antiaromatic double aza[7]helicene C that features NN-embedded polycyclic aromatic hydrocarbons (PAHs). This heteroatom-doped helicene showed a rarely obtained long-wavelength emission and far-red circularly polarized luminescence (CPL) in the solid state. These optical and chiroptical properties could be ascribed to both the NN-PAH core structure and the further extension through angular ring fusions.

Expanding new chemistry of aza-boracyclophanes with unique dipolar structures, AIE and redox-active open-shell characteristics.

π-Conjugated macrocycles involving electron-deficient boron species have received increasing attention due to their intriguing tunable optoelectronic properties. However, most of the reported B(sp)-doped macrocycles are difficult to modify due to the synthetic challenge, which limits their further applications. Motivated by the research of non-strained hexameric bora- and aza-cyclophanes, we describe a new class of analogues MC-BN5 and MC-ABN5 that contain charge-reversed triarylborane (ArB) units and oligomeric triarylamines (ArN) in the cyclics.

A New Platform of B/N-Doped Cyclophanes: Access to a π-Conjugated Block-Type B N Macrocycle with Strong Dipole Moment and Unique Optoelectronic Properties.

We herein describe a new design principle to achieve B/N-doped cyclophane where an electron-donor block of three triarylamines (Ar N) and an acceptor block of three triarylboranes (Ar B) are spatially separated on opposite sides of the π-extended ring system. DFT computations revealed the distinct electronic structure of the block-type macrocycle MC-b-B3N3 with a greatly enhanced dipole moment and reduced HOMO-LUMO energy gap in comparison to its analogue with alternating B and N sites, MC-alt-B3N3. The unique arrangement of borane acceptor Ar B and amine donor Ar N components in MC-b-B3N3 induces exceptionally strong intramolecular charge transfer in the excited state, which is reflected in a largely red-shifted luminescence at 612 nm in solution.

Oligotriarylamine-Extended Organoboranes with Tunable Electron-Donating Strength by Changing the Number of Donor Units.

Triarylborane (ArB) and triarylamine (ArN) have been widely employed to construct electronically different donor-acceptor (D-A) systems. Herein, we describe a series of A-D-A-type luminescent organoboranes ( = 1, 3, 5) that show an increased number of ArN units as electron donors and two terminal ArB as acceptors. When the ArN moieties were extended from one to five units, their electron-donating strength was gradually enhanced and the highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) energy gaps could also be tuned, which was further reflected in the red-shifted emissions from blue (λ = 458 nm) to orange (λ = 595 nm) with a decrease in from 3.

MiR-216b suppresses cell proliferation, migration, invasion, and epithelial-mesenchymal transition by regulating FOXM1 expression in human non-small cell lung cancer.

MiR-216b and forkhead box M1 (FOXM1) were demonstrated to exert their biological effects on the development and progression of tumors. This study aimed to investigate the expression and role of miR-216b and FOXM1 in tissues and cell lines of non-small cell lung cancer (NSCLC). The expressions of miR-216b and FOXM1 in NSCLC tissues and cells were detected by qRT-PCR and Western blot analysis.