Publications by authors named "Yavuz S Sanisoglu"
Objective: As little is known about relationship between acylation stimulating protein (ASP) and oxidative stress, whether there is any link between ASP and oxidative stress in young obese males were investigated.
Design And Methods: Forty-five obese (median body mass index (BMI) = 36.99 (IQR = 3.
High Frequency of Inherited Variants in the MEFV Gene in Acute Lymphocytic Leukemia.
Indian J Hematol Blood Transfus
September 2011
In the present study, we aimed to determine the frequency of inherited variants in the MEFV (Mediterranean FeVer), the gene responsible for familial Mediterranean fever (FMF), gene in patients with acute lymphocytic leukemia (ALL). The eight MEFV gene variants (M694I, M694V, M680I (G/C-A), V726A, R761H, E148Q and P369S) were detected in 36 patients with ALL and 65 healthy controls; none had own and/or family history compatible with FMF. We identified 11 heterozygous inherited variants in the MEFV gene in both ALL patients and controls.
View Article and Find Full Text PDFPurpose: To provide insight into the factors by which obesity in itself may directly lead to early arterial damage, we aimed to determine early sonographic markers of obesity-related vascular dysfunction in young obese males.
Methods: Thirty-five young obese males and 23 age-matched healthy male volunteers were recruited into the study. Common carotid artery pulsatility index and resistance index were calculated from blood flow velocities curves obtained by pulsed Doppler ultrasonography.
We investigated the frequency of inherited variants in the MEFV gene, which is mutated in familial Mediterranean fever (FMF), in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Eight MEFV gene variants (M694I, M694V, M680I (G/C-A), V726A, R761H, E148Q and P369S) were analyzed in 33 MDS patients, 47 AML patients and 65 healthy controls; none had a history or family history compatible with FMF. We identified two homozygous (E148Q/E148Q), one compound heterozygous (M694V/E148Q) and five heterozygous inherited variants in the MEFV gene in AML patients.
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- The study investigates how body iron levels and oxidative stress relate to cognitive function in elderly nursing home residents, measuring their cognitive status using the Mini-Mental State Examination (MMSE).
- Among 87 participants, those with cognitive dysfunction had higher serum iron and malondialdehyde (MDA) levels, but lower glutathione peroxidase (GSH-Px) enzyme activity compared to their cognitively normal counterparts.
- The findings suggest that elevated iron markers and oxidative stress are linked to cognitive dysfunction, yet no direct correlation was found between iron deposition and oxidative stress, indicating a need for further research on potential treatments.
We aimed to investigate the rate of MEFV, the gene mutated in familial Mediterranean fever, mutations in patients with myeloid neoplasm and to determine if known mutations of MEFV cause a tendency for myeloid neoplasms. The frequency of the five most common MEFV gene mutations (M694V, M680I, V726A, E148Q and M694I) was determined in 26 patients with myeloid neoplasm. We identified 1 homozygous (E148Q/E148Q), 1 compound heterozygous (M694V/E148Q) and 5 heterozygous MEFV gene mutations; none had their own and/or family history compatible with familial Mediterranean fever.
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- This study aimed to explore how anaemia affects cognitive functions and daily living activities in elderly individuals.
- Conducted with 180 participants, the results showed that anaemic individuals had lower haemoglobin levels and performed worse on cognitive tests (MMSE) and daily activities than nonanaemic individuals.
- The findings suggest that anaemia in the elderly leads to increased dependency in daily tasks and impaired cognitive abilities, indicating the need for better management of anaemia in this population.
Article Synopsis
- The study explores the relationship between serum asymmetric dimethylarginine (ADMA) levels, a marker of endothelial dysfunction, and familial Mediterranean fever (FMF), finding that FMF patients have higher ADMA and C-reactive protein (CRP) levels than healthy controls.
- Researchers assessed 38 male FMF patients and 23 healthy volunteers, noting that ADMA levels increased during acute attacks and were lower in patients using colchicine.
- The findings suggest that elevated ADMA may reflect inflammation-related endothelial dysfunction in FMF, and regular colchicine treatment could play a role in preventing both this dysfunction and amyloidosis.*
Fibrous dysplasia of bone is an enigma with no known cure. Treatment currently consists of curettage and bone-grafting in an attempt to eradicate the lesion and to prevent progressive deformity. This study presents the results of prophylactic intramedullary nailing in 10 patients with monostotic fibrous dysplasia, pain increasing with movement, and scintigraphically established activity.
View Article and Find Full Text PDFAim: There are no studies that examine the circulating acylation-stimulating protein (ASP) levels in patients with polycystic ovary syndrome (PCOS). The present study was designed to determine the ASP levels in PCOS and to evaluate the effect of metformin on plasma fasting ASP concentrations.
Methods: Twenty women with PCOS and 20 healthy controls matched for age and body mass index (BMI) were included in the study.