Clinical outcomes of laser vaporization for vaginal intraepithelial neoplasia - A 20-year retrospective review.

Objectives: The purpose of our study is to evaluate clinical outcomes of CO2 laser vaporization in patients with high-grade vaginal intraepithelial neoplasia (VAIN), and analyze potential risk factors for unfavourable outcome.

Study Design: A retrospective cohort study was carried out on all patients with high-grade VAIN treated by laser vaporization from Jan 2001 to Dec 2020 in a gynae-oncology training centre in Hong Kong.

Results: A total of 116 women underwent laser therapy for high-grade VAIN during the study period and the median follow-up time was 49.