Role of Genetic Mutations in Periodontitis Patients with Cardiovascular Diseases and Allied Ailments: A Systematic Review and Meta-analysis.

Background: Periodontal disease, a chronic inflammatory condition, has been increasingly associated with systemic health issues, particularly cardiovascular diseases. This systematic review and meta-analysis explores the role of genetic mutations in periodontitis patients with cardiovascular diseases and allied ailments.

Methodology: Conducted a comprehensive search across databases including PubMed, EMBASE, and Cochrane Library to identify relevant studies on the association between genetic mutations, periodontal disease severity, and cardiovascular outcomes.

Vascular Inflammatory Genes as Predictors of Preeclampsia: A Systematic Review.

Background: Preeclampsia, a condition causing new-onset hypertension and proteinuria after 20 weeks of gestation, is a significant cause of maternal and fetal morbidity and mortality. The pathogenesis of preeclampsia is complex, involving an interplay of vascular inflammation and angiogenic imbalance. This systematic review and meta-analysis aims to elucidate the role of key vascular inflammatory candidate genes-VEGF, TNF-α, IL-10, and LPL-in the onset of preeclampsia.