Effect of mechanical strain-induced PGE production on bone nodule formation by rat calvarial progenitor cells.

High-magnitude mechanical strain inhibits bone nodule formation by reducing expression of bone morphogenetic protein-2 (BMP-2), Runt-related transcription factor 2 (Runx2), and muscle segment homeobox 2 (Msx2). Mechanical strain also induces production of proinflammatory factor prostaglandin E (PGE) by osteoblasts. We measured the effect of mechanical strain-induced PGE production on bone nodule formation and expression levels of bone formation-related factors.

High-magnitude mechanical strain inhibits the differentiation of bone-forming rat calvarial progenitor cells.

Purpose: Orthodontic tooth movement occurs during the bone remodeling induced by therapeutic mechanical strain. It is important to investigate the relation between the strength of mechanical stress and bone formation activity. The aim of this study was to determine the effect of high-magnitude mechanical strain on bone formation in detail.