Publications by authors named "Yasuto Shimomura"
The characteristics and prognosis of Japanese children with acute lymphoblastic leukemia (ALL) who fail to achieve complete remission after remission induction chemotherapy (i.e., experience induction failure) are poorly understood.
View Article and Find Full Text PDFCase Report: Acquired Generalized Anhidrosis Caused by Brain Tumor: Review of the Literature.
Front Endocrinol (Lausanne)
June 2022
Article Synopsis
- * Two case studies detail a 12-year-old boy and girl, both diagnosed with germinoma, who experienced generalized anhidrosis; after treatment with chemotherapy and radiation, the boy showed partial improvement while the girl had complete resolution of sweating.
- * The study highlights that while germinoma can lead to anhidrosis, the extent of hypothalamic involvement may influence the recovery of sweating in patients, with those having hypothalamic issues showing less improvement.
Article Synopsis
- A 9-year-old boy with leukemia had an unusual reaction to high doses of methotrexate, experiencing hypersensitivity and acral erythema, which are rare side effects.
- The symptoms were assessed for severity, and strategies like slowing the infusion rate and providing premedication allowed the boy to continue his treatment.
- Acral erythema improved with basic supportive care, and it was concluded that such reactions can happen even in the first treatment course without needing to change the overall chemotherapy plan unless absolutely necessary.
Article Synopsis
- Hunter syndrome is an X-linked disorder caused by a deficiency in iduronate-2-sulfatase, which has recently been linked to embolic strokes.
- A case study of a 23-year-old Japanese man with this condition revealed he experienced a subcortical infarction resembling branch atheromatous disease, despite being on treatment.
- Findings included thickening of the middle cerebral artery and impaired vasodilation, indicating potential complications in the cerebral arteries related to the disease, highlighting the need to explore the mechanisms behind cerebral infarction in Hunter syndrome patients.
A 1-year-old boy presented with a 4-month history of hypertension, ptosis of the right upper eyelid, left hemifacial sweating, and flushing. He was diagnosed with Harlequin syndrome associated with Horner syndrome. Computed tomography revealed a mass lesion in the right superior mediastinum.
View Article and Find Full Text PDFInduction deaths (ID) remain a critical issue in the treatment of pediatric patients with acute lymphoblastic leukemia (ALL). The reported rate of ID in this population is 1% or higher. We speculate that this proportion might be lower in Japan because of mandatory hospitalization during induction therapy to manage complications.
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- The study investigated factors that can predict how effective intravenous immunoglobulin (IVIG) therapy is for children with Kawasaki disease (KD) by analyzing data from 77 patients treated with IVIG.
- When comparing laboratory results before and 24 hours after IVIG treatment, responders showed significantly lower white blood cell (WBC) and neutrophil counts than nonresponders, who experienced recurring fever.
- The findings suggested that monitoring WBC and neutrophil counts within the first day post-treatment can effectively predict IVIG therapy outcomes and identify patients who may not respond to the treatment.
Clinical Case: We report on a 7-year-old female with spinal pilocytic astrocytoma complicated by pseudoprogression 1 month after completion of radiation therapy. Although she was initially treated with high-dose steroids, her clinical symptoms did not completely resolve, and magnetic resonance imaging (MRI) revealed extension of the lesions into the medulla oblongata. Treatment with bevacizumab was commenced, followed by rapid resolution of the clinical symptoms and improvements in the MRI findings.
View Article and Find Full Text PDFA 6-year-old girl was admitted with a mass lesion in the cerebellar vermis. She underwent subtotal tumor resection, and on immunohistopathology the tumor consisted of two different parts: typical medulloblastoma (MB) characteristics and atypical teratoid/rhabdoid tumor (AT/RT) features, despite positive integrase interactor 1 expression. The patient was diagnosed with MB with epithelioid features.
View Article and Find Full Text PDFWe encountered 2 immunocompromised children complicated by Raoultella ornithinolytica bacteremia. One had received methylprednisolone pulse therapy for IgA nephropathy, and the other had leukopenia because of chemotherapy for leukemia. Both children had no specific symptoms, and R.
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- Steroid-induced osteonecrosis (ON) is a significant complication in children undergoing chemotherapy for acute lymphoblastic leukemia (ALL), and its incidence was studied in 1,095 patients across three different treatment protocols.
- The cumulative incidence of ON was found to vary between protocols: 0.76% in ALL941, 0.35% in ALL2000, and increased to 3.6% in ALL2004, which utilized dexamethasone alongside prednisolone.
- The study identified that girls aged 10 and older have a notably higher risk for developing ON compared to younger children and boys, highlighting the need for careful risk assessment when using dexamethasone in this demographic.
Background: The aim of the JCCLSG AML 9805 Down study was to evaluate the effect of continuous and high-dose cytarabine combined chemotherapy on the survival outcome of acute myeloid leukemia (AML) with Down syndrome (DS).
Procedure: From May 1998 to December 2006, DS patients with newly diagnosed AML were enrolled. Remission induction therapy consisted of two courses of pirarubicin, vincristine, and continuous-dose cytarabine (AVC1).
Background: Pirarubicin (tetrahydropyranyl-adriamycin: THP) is a derivative of doxorubicin with reportedly less cardiotoxicity in adults. However no studies of cardiotoxicity in children treated with THP have been reported. This study was performed to assess the THP-induced cardiotoxicity for children with acute lymphoblastic leukemia (ALL).
View Article and Find Full Text PDFBackground: The majority of minimal residual disease (MRD)-positive patients with acute lymphoblastic leukemia (ALL) have poor outcomes. The ALL2000 study was performed to evaluate the efficacy of augmented chemotherapy based on MRD-restratification in childhood ALL.
Procedure: Between 2000 and 2004, 305 eligible patients with precursor B or T-cell ALL were enrolled in the ALL2000 study.
In the NHL960 non-LB study, we treated diffuse large B-cell lymphoma (DLBCL) using a short-term ALL-like protocol. Thirty children up to 16 years of age with DLBCL were stratified into group 1 with stage I/II disease, or group 2 with stage III/IV disease. Their ages ranged from 9 months to 16 years of age, with a median of 9 years of age.
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