Publications by authors named "Yasutaka Yamanaka"
Article Synopsis
- The COVID-19 pandemic led to a significant decline in RSV infections in 2020, but in 2021, an unusual spike and irregular seasonal patterns were observed globally, including in Osaka, Japan.
- By 2022, the epidemic size returned to normal, yet the onset timing of RSV infections remained unpredictable for 2022 and 2023.
- Attempts to forecast the 2023 RSV epidemic using historical data were unsuccessful, indicating that the seasonal patterns of RSV are still disrupted post-pandemic and that future monitoring is necessary.
Article Synopsis
- Respiratory syncytial virus (RSV) in Japan has shown unusual seasonality patterns since 2017, shifting from a typical autumn-winter peak to a summer-autumn pattern, with varied reporting in subsequent years.
- Researchers developed reference thresholds for detecting the start of RSV epidemics using case data, employing a relative operating characteristic curve analysis.
- The established case-per-sentinel (CPS) values for major prefectures in Japan could help in early detection of RSV epidemics and support the potential introduction of monoclonal antibodies for prevention.
Calcium homeostasis endoplasmic reticulum protein (CHERP) is colocalized with the inositol 1,4,5-trisphosphate receptor (IP3R) in the endoplasmic reticulum or perinuclear region, and has been involved in intracellular calcium signaling. Structurally, CHERP carries the nuclear localization signal and arginine/serine-dipeptide repeats, like domain, and interacts with the spliceosome. However, the exact function of CHERP in the nucleus remains unknown.
View Article and Find Full Text PDFCancer cells often exhibit extreme sensitivity to splicing inhibitors. We identified food-derived flavonoids, apigenin and luteolin, as compounds that modulate mRNA splicing at the genome-wide level, followed by proliferation inhibition. They bind to mRNA splicing-related proteins to induce a widespread change of splicing patterns in treated cells.
View Article and Find Full Text PDF[This corrects the article DOI: 10.1371/journal.pone.
View Article and Find Full Text PDFDBP5, also known as DDX19, GLE1 and inositol hexakisphosphate (IP6) function in messenger RNA (mRNA) export at the cytoplasmic surface of the nuclear pore complex in eukaryotic cells. DBP5 is a DEAD-box RNA helicase, and its activity is stimulated by interactions with GLE1 and IP6. In addition, these three factors also have unique role(s).
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