Publications by authors named "Yasushi Kusunoki"
Article Synopsis
- The prognosis for chronic myeloid leukemia (CML) in blastic crisis is generally poor, but some patients can achieve long-term remission through allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- A specific case showed that after receiving a KIR3DL1 allelic-mismatched transplant, the patient initially had reduced leukemia levels and increased NK cell activity, but this effect was temporary.
- The study highlights the importance of KIR3DL1 in the effectiveness of NK cell-mediated anti-leukemia activity post-transplant, suggesting that choosing donors lacking KIR3DL1 alleles could lead to better treatment outcomes for CML patients.
Response to tyrosine kinase inhibitors (TKIs) is variable in chronic myeloid leukemia (CML), and elevated natural killer (NK) cells during TKI therapy are positively correlated with superior outcomes. NK cell function involves interactions of their killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I on target cells, and the avidity of KIR-HLA interactions depends on the combination of and alleles. We hypothesized that and polymorphisms may influence response to TKIs.
View Article and Find Full Text PDFWe report a pilot series of five patients who received stem cell transplantation (SCT) from a spouse for post-transplant relapse or rejection. The inclusion criterion regarding HLA disparities was three or fewer antigen mismatches in the graft-versus-host direction at the HLA-A, B, and DR loci. Four patients received spousal SCT as a third transplant attempt after post-transplant relapse and one as rescue for graft rejection.
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