Publications by authors named "Yasuo To"

Article Synopsis
  • * A total of 81 patients were included, with 63 in the chronic ILD group and 18 in the acute ILD group; several serum markers such as TAT, D-dimer, and SP-D were analyzed.
  • * In AE-ILD, SP-D levels positively correlated with various coagulation markers, suggesting that these coagulation indicators may help in diagnosing AE-ILD alongside traditional alveolar damage markers.
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Background: No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT.

Methods: For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021.

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Article Synopsis
  • Obesity-related non-eosinophilic asthma has been recognized as a distinct asthma phenotype, with treatments like mepolizumab and omalizumab showing benefits for severe cases in obese patients, suggesting a potential role for type-2 cytokines.
  • This study focused on examining the clinical characteristics of obese asthmatic patients based on the presence of positive type-2 inflammation markers, dividing them into two groups: T2 (positive markers) and NT2 (negative markers).
  • Results indicated that the T2 group experienced more persistent asthma since childhood, had higher rates of allergic rhinitis, and reported more severe symptoms requiring high-dose inhaled corticosteroids, with a greater frequency of acute exacerbations.
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Article Synopsis
  • * It included 146 patients, measuring the correlation between anti-SARS-CoV-2 S antibodies and factors like IFN-λ3 and oxygen demand, finding that low antibody levels could indicate higher oxygen needs in patients.
  • * The research suggests that assessing anti-SARS-CoV-2 S antibodies and IFN-λ3 levels could be vital for predicting patient care requirements, especially differentiating COVID-19 pneumonia from aspiration pneumonia.
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The aim of this study was to determine the efficacy and safety of ciclesonide in the treatment of novel coronavirus disease 2019 (COVID-19) as gauged by pneumonia progression. This multi-center, open-label randomized trial was conducted with patients recruited from 22 hospitals across Japan. Participants were patients admitted with mild or asymptomatic COVID-19 without signs of pneumonia on chest X-rays.

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Recent advance of medications and devices brings more effective treatment intervention to the patients with asthma. As far as obeying guidelines, approximately 90% of patients with asthma acquire good control. However, there are still small number of patients with asthma who resist conventional treatment.

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Objectives: This study aims to create and validate a useful score system predicting the hyper-inflammatory conditions of COVID-19, by comparing it with the modified H-score.

Methods: A total of 98 patients with pneumonia (without oxygen therapy) who received initial administration of casirivimab/imdevimab or remdesivir were included in the study. The enrolled patients were divided into two groups: patients who required corticosteroid due to deterioration of pneumonia, assessed by chest X-ray or CT or respiratory failure, and those who did not, and clinical parameters were compared.

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Background: There are limited studies on healthcare resource use (HCRU) among adult asthma patients in Japan using real-world evidence, and analysis on acute treatment and associated costs stratified by disease severity is further limited. This study aimed to characterize the disease burden of severe asthma patients in Japan in terms of HCRU and comorbid medical conditions, with particular interest in oral corticosteroid (OCS) dependency.

Methods: This retrospective cohort study of asthma patients used data from a claims database of diagnosis procedure combination hospitals in Japan.

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Cigarette smoke impairs autophagy, an intracellular protein degradation system, but the consequences of this defect have not been fully elucidated, especially in macrophages. Dysfunctional alveolar macrophages play an important role in chronic obstructive pulmonary disease (COPD). Here we show that galectin-8, a danger receptor that identifies damaged intracellular host vesicles and initiates autophagosome engulfment, is elevated due to activation of autophagy by cigarette smoke extract (CSE) in macrophages.

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Background: Fungal sensitization is a risk factor for severe asthma. Colonization in the lower respiratory tract is one of the forms of fungal exposure, and it is related to fungal sensitization. Pulmonary emphysema was recently reported to be an underlying disease of fungal colonization.

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Background: In approximately 30% of children with asthma, the condition persists into adulthood. The longer duration of asthma in these patients is a risk factor for poor asthma control. However, the characteristics of adult patients with asthma that has persisted since childhood are not well documented.

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Background: Severe asthma is increasingly being recognized as an important public health issue. Obesity has been identified as a risk factor for poor asthma control and for worsening of asthma severity. However, most studies investigating obese patients with asthma have been performed in Western countries.

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Background: Maintaining high treatment adherence levels is critical for effective management of chronic diseases. The Adherence Starts with Knowledge 20 (ASK-20) questionnaire is the only linguistically validated patient-reported treatment adherence tool available in Japan. We conducted additional analyses on ASK-20 data from Japanese adults with asthma.

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