[Design of X-ray Images Based on Quantitative Analysis: Predictive Model of Image Quality and Physical Quantity Factors by Multiple Regression Equation of Visual Evaluation (Scheffé's) and Physical Quantities (Dose and Noise)].

Purpose: The Scheffé's method obtains the difference between pair comparisons with that of the interval scale and can judge the superiority or inferiority of the sample to be compared with no restriction in the observation image by the statistical significant difference. However, the Scheffé's method cannot be judged as a single image quality indicator. Therefore, I examined a method that can evaluate the association of average degree of preference of Scheffé's method and the physical quantities that make up the image.

[Evaluation study of abnormal detectability with Thurstone and Scheffé (Nakaya) of paired comparison method using chest phantom].

Monitors are increasingly being used as diagnostic imaging devices. In this study, using an all-purpose liquid-crystal display (LCD), the rate of detection of abnormalities was investigated using Thurstone's and Scheffé's (Nakaya) paired comparison methods. A chest phantom was prepared as a test sample with acryl and aluminum plates and intensities suggesting small adenocarcinomas.

Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells.

Polyglutamylation is a new class of posttranslational modification in which glutamate side chains are formed in proteins, although its biological significance is not well known. Through our genome-wide gene expression profile analyses of pancreatic ductal adenocarcinoma (PDAC) cells, we identified the overexpression of tubulin tyrosine ligase-like family member 4 (TTLL4) in PDAC cells. Subsequent reverse transcription-PCR and Northern blot analyses confirmed its upregulation in several PDACs.

[Estimation of appropriate dose for computed radiography by the threshold value of the image quality figure].

We estimated the optimum dose for imaging with a computed radiography (CR) system at two different pixel sizes based on the area under curve (AUC) in receiver operating characteristic (ROC) analysis and image quality figure (IQF). Samples for ROC analysis were prepared as follows. Acryl beads, 2.

Cell cycle phenotype-based optimization of G2-abrogating peptides yields CBP501 with a unique mechanism of action at the G2 checkpoint.

Cell cycle G(2) checkpoint abrogation is an attractive strategy for sensitizing cancer cells to DNA-damaging anticancer agent without increasing adverse effects on normal cells. However, there is no single proven molecular target for this therapeutic approach. High-throughput screening for molecules inhibiting CHK1, a kinase that is essential for the G(2) checkpoint, has not yet yielded therapeutic G(2) checkpoint inhibitors, and the tumor suppressor phenotypes of ATM and CHK2 suggest they may not be ideal targets.

[Sensitometry of Mammographic Screen-film System Using Bootstrap Aluminum Step-Wedge.].

Recently, a few types of step-wedges for bootstrap sensitometry with a mammographic screen-film system have been proposed. In this study, the bootstrap sensitometry with the mammographic screen-film system was studied for two types of aluminum step-wedges. Characteristic X-ray energy curves were determined using mammographic and general radiographic aluminum step-wedges devised to prevent scattered X-rays generated from one step penetrating into the region of another one, and dependence of the characteristic curves on the wedges was also discussed.

[Fundamental study on stability of dry-processing imager system DRYPRO 722/SD-P].

Dry-processing leaser imager systems have become popular due to the advantages such as the elimination of the cost and labor associated with the wet chemical processing. In this paper, the stability of a dry-processing imager system Drypro 722/SD-P was studied using SMPTE pattern films processed by a dry-processing imager Drypro 722 and a wet-processing imager Li-8/SRX-502 at three different times of the day over a period of five consecutive working days. The dry system is inferior to the wet system on the stability and the spatial uniformity, so that the problems assess the necessity of QC for Drypro 722 Laser Imagers.

Nonlinear Effect on Noise Power Spectrum for Quantum Mottle in Radiographs.

Rossmann's formula on the power spectrum of quantum noise in a radiograph is based on an assumption that the relation between the spatial fluctuations of optical density and the relative spatial fluctuations of light energy irradiated from the intensifying screen due to absorbed x-ray quanta is linear. The reasonability of the assumption is not theoretically obvious because the relative spatial fluctuation of light energy increases as the number of absorbed x-ray quanta decreases. Based on the shot-noise theory, the power spectrum of quantum noise is calculated taking account of the second order of the spatial fluctuation of light energy and the spectrum is expressed as a function of the gradient, the modulation transfer function of the screen-film system, and the average number of absorbed x-ray quanta.