Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring.

Background: Management of postprandial hyperglycemia is a key aspect in diabetes treatment. We developed a novel system to measure glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET) for simple monitoring of postprandial glucose excursions. In this study, we evaluated the relationship between our system and continuous glucose monitoring (CGM) by comparing glucose AUC obtained using MIET with that obtained using CGM for a long duration.

A minimally invasive system for glucose area under the curve measurement using interstitial fluid extraction technology: evaluation of the accuracy and usefulness with oral glucose tolerance tests in subjects with and without diabetes.

Background: Recent studies have highlighted the importance of managing postprandial hyperglycemia, but adequate monitoring of postprandial glucose remains difficult because of wide variations in levels. We have therefore developed a minimally invasive system to monitor postprandial glucose area under the curve (AUC). This system involves no blood sampling and uses interstitial fluid glucose (IG) AUC (IG-AUC) as a surrogate marker of postprandial glucose.

Measurement of glucose area under the curve using minimally invasive interstitial fluid extraction technology: evaluation of glucose monitoring concepts without blood sampling.

Background: Monitoring postprandial hyperglycemia is crucial in treating diabetes, although its dynamics make accurate monitoring difficult. We developed a new technology for monitoring postprandial hyperglycemia using interstitial fluid (ISF) extraction technology without blood sampling. The glucose area under the curve (AUC) using this system was measured as accumulated ISF glucose (IG) with simultaneous calibration with sodium ions.

Oriented attachment-based assembly of dendritic silver nanostructures at room temperature.

How particles aggregate into an interesting dendritic structure has been the object of research for many years because of its importance in understanding physical processes involved and in designing novel materials. In this work, we for the first time describe an oriented attachment-based assembly mechanism for formation of different types of dendritic silver nanostructures at room temperature. It is found that the concentration of both AgNO(3) and p-aminoazobenzene (PA) molecules has a significant effect on the formation and growth of these novel nanostructures.

Variations in steady-state and time-resolved background luminescence from surface-enhanced resonance Raman scattering-active single Ag nanoaggregates.

We observed a background luminescence emission that was associated with surface-enhanced resonance Raman scattering (SERRS) of rhodamine 6G (R6G) molecules adsorbed on single Ag nanoaggregates and investigated the origin of the background luminescence. Thanks to the observation of single nanoaggregates, we clearly identified nanoaggregate-by-nanoaggregate variations in the steady-state and time-resolved background luminescence spectra of each nanoaggregate. From the variations in the steady-state spectra, two kinds of key properties were revealed.

Surface-enhanced resonance Raman scattering and background light emission coupled with plasmon of single Ag nanoaggregates.

We investigated the optical properties of isolated single aggregates of Ag nanoparticles (Ag nanoaggregates) on which rhodamine 6G molecules were adsorbed to reveal experimentally a correlation among plasmon resonance Rayleigh scattering, surface-enhanced resonance Raman scattering (SERRS), and its background light emission. From the lack of excitation-laser energy dependence of background emission maxima we concluded that the background emission is luminescence, not Raman scattering. The polarization dependence of both SERRS and background emission was the same as that of the lowest-energy plasmon resonance maxima, which is associated with a longitudinal plasmon.

Designed fabrication of ordered porous au/ag nanostructured films for surface-enhanced Raman scattering substrates.

This article reports the designed preparation of two different kinds of novel porous metal nanostructured films, namely, an ordered macroporous Au/Ag nanostructured film and an ordered hollow Au/Ag nanostructured film. Different from previous reports, the presently proposed method can be conveniently used to control film structures by simply varying the experimental conditions. The morphology of these films has been characterized by scanning electron microscopy (SEM), and their performance as surface-enhanced Raman scattering (SERS) substrates has been evaluated by using rhodamine 6G (R6G) as a probe molecule.