Publications by authors named "Yasunori Kawate"
Res Pract Thromb Haemost
May 2024
Article Synopsis
- Acquired von Willebrand syndrome (AVWS) is linked to cardiovascular diseases like mitral regurgitation (MR), leading to a decrease in large von Willebrand factor (VWF) multimers, but its specifics with MR are still not fully understood.
- A study analyzed 84 patients with moderate to severe MR, finding that 69% exhibited a significant loss of VWF large multimers, especially in degenerative MR cases, but levels improved after mitral valve intervention.
- The findings indicate that while MR is commonly associated with loss of VWF large multimers, the overall risk of gastrointestinal bleeding remains low, and hemoglobin levels tend to stay stable post-treatment.
Res Pract Thromb Haemost
January 2024
Article Synopsis
- Severe aortic stenosis (AS) can lead to acquired von Willebrand syndrome by breaking down important blood clotting factors, requiring accurate diagnosis methods to identify the condition.*
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- The study evaluated the effectiveness of the VWF Ristocetin co-factor activity to antigen levels (VWF:RCo/VWF:Ag) ratio as a diagnostic tool for AS-induced von Willebrand syndrome using data from 382 AS patients and controls.*
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- Results showed a VWF:RCo/VWF:Ag ratio of <0.7 is specific for detecting loss of important blood clotting multimers in patients with AS, but it has low sensitivity, indicating it might miss some cases.*
