Publications by authors named "Yasunari Ohno"

Background: In liver transplant patients with hypoplastic portal vein (PV), when the narrowed segment is extended too deep into the dorsal side of the pancreas, it is difficult and dangerous to reconstruct the interposition graft from the upper part of the pancreas. Herein, we present a case of PV reconstruction with the autologous mesosystemic shunt vessel from the caudal side of the pancreas in a situation where the narrowed PV was deep, and we discuss the technical details.

Case Presentation: A 25-year-old woman presented with cholestatic liver cirrhosis due to biliary atresia after Kasai procedure.

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Background: Children requiring liver transplantation generally have severe growth retardation. Recipients experience posttransplantation catch-up growth, although some show short adult heights. We aimed to determine decades-long catch-up growth trends and risk factors for short adult height following liver transplantation.

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Article Synopsis
  • * Analyzing 125 liver transplant recipients, results showed that after the second and third vaccine doses, 89.1% and 100% had a positive antibody response, although antibody levels declined significantly over time.
  • * The findings suggest that liver transplant recipients achieve a comparable immune response to healthy individuals, indicating the importance of booster shots for maintaining immunity.
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Background: The incidence of de novo malignancy (DNM) after liver transplantation (LT) is reported to be 3.1% to 14.4%.

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Background: Leiomyosarcoma is classified as a soft tissue sarcoma. In adults, leiomyosarcoma is the most common malignancy affecting the vascular system; however, vascular leiomyosarcoma in children is extremely rare as most pediatric soft tissue tumors are rhabdomyosarcomas. The survival rate is very low, and incomplete resection is a poor prognostic factor.

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Background: Although chronic kidney disease (CKD) after liver transplantation (LTx) is a common complication in adults, its long-term significance after pediatric LTx remains unclear. We examined the decades-long transition of renal function and revealed the risk factors for late-onset CKD after pediatric LTx in a single-center retrospective cohort of 117 pediatric LTx recipients who survived >5 y.

Methods: The estimated glomerular filtration rate (eGFR) and CKD stages were calculated using serum creatinine.

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  • Fungal infections can arise in organ transplant patients due to immunosuppression, with severe types like mucormycosis posing significant health risks.
  • A 47-year-old man received an ABO-incompatible liver transplant but later developed disseminated mucormycosis caused by Cunninghamella bertholletiae, leading to multiple organ complications.
  • Despite treatment efforts with amphotericin B, the patient suffered cardiac failure and ultimately died 27 days post-transplant, with autopsy findings showing widespread fungal invasion in various organs.
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  • Living donor liver transplantation (LDLT) is widely used, but it carries the risk of small-for-size syndrome (SFSS), particularly in partial liver grafts for adult recipients.
  • SFSS is influenced by persistent portal vein hypertension and hyper-perfusion, leading to various strategies like portocaval shunt and splenic artery ligation to manage portal vein flow and pressure.
  • Improving surgical techniques and addressing recipient factors, such as nutrition and muscle mass, are essential for reducing the risk of SFSS and enhancing patient outcomes.
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Background And Objective: Liver transplantation (LT) is the gold-standard treatment for end-stage liver disease; however, late-onset complications such as fatty liver can occur in the absence of metabolic comorbidities. We report a unique case of post-transplant hepatic steatosis developing in only a part of the liver graft.

Case Report: A 1-year-old boy underwent ABO-incompatible living donor liver transplantation (LDLT) with a left lateral liver graft donated from his mother for biliary atresia.

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Insulinoma is a rare neuroendocrine tumor that causes hypoglycemia due to unregulated insulin secretion. Blood glucose management during insulinoma resection is therefore challenging. We present a case in which real-time subcutaneous continuous glucose monitoring (SCGM) in combination with intermittent blood glucose measurement was used for glycemic control during surgery for insulinoma resection.

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To introduce duct-to-duct biliary anastomosis to conventional temporary auxiliary partial orthotopic liver transplantation (APOLT) using living donor graft for patients with familial amyloid polyneuropathy, we modified the conventional APOLT procedure in a manner characterized by the use of the recipient's common hepatic duct for biliary reconstruction and the preservation of the right posterior section alone for the certain placement of a tube into the corresponding biliary tree for external biliary drainage (modified APOLT). This procedure was performed in 3 patients without biliary complications. No complications associated with the external drainage tube occurred.

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Aims: Recurrent hepatitis is a significant complication after liver transplantation for hepatitis C virus (HCV) disease. To evaluate responsiveness to treatment of HCV disease after liver transplantation, in situ hybridisation (ISH) was employed.

Methods: Sense and anti-sense probes for HCV were synthesised, and ISH studies were performed on 19 liver biopsy specimens from 19 recipients who had undergone living donor liver transplantation for HCV disease.

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We have previously reported that a graft volume (GV) > 30% of the recipient's standard liver volume (SLV) can meet the recipient's metabolic demands. Here we report our experience with adult-to-adult living donor liver transplantation using left side grafts < 35% of the recipient's SLV. Of 143 adult living donor liver transplants, 13 auxiliary partial orthotopic liver transplants, 8 right side grafts, and 2 retransplantation cases were excluded.

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Background/purpose: This study was carried out to investigate the risk factors contributing to hepatic artery thrombosis in living-donor liver transplantation.

Methods: Two hundred and twenty-two recipients (113 adults and 109 children) of living-donor liver transplantation were the subjects of this study. The diagnosis of hepatic artery thrombosis was made by color-Doppler ultrasonography and/or hepatic angiography.

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We treated 7 patients with locoregional lymph node recurrence of estrogen-receptor-negative breast cancer with weekly paclitaxel (TXL) therapy. TXL was administered by 30-minute infusion at a dose of 80 mg/m2 after short premedication every week on an outpatient basis. Administration was continued for 3 weeks with a 1 week rest.

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A 33-year-old patient with familial amyloid polyneuropathy (FAP) underwent temporary auxiliary partial orthotopic liver transplantation (APOLT) from a living donor with a small-for-size graft. The auxiliary left lobar graft, which weighed only 230 g, was orthotopically transplanted after resection of the recipient's left lobe. The right portal vein was transected to induce compensatory hypertrophy of the left lobar graft.

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