Publications by authors named "Yasuko Sakoda"
Article Synopsis
- This study focused on how lenalidomide and bortezomib affect bone health in patients with multiple myeloma, specifically looking at bone microarchitecture and biomechanics through CT scans and finite element modeling (FEM).
- Thirty-two patients received bortezomib and 18 received lenalidomide, with results indicating that bortezomib led to decreased bone strength measurements, while lenalidomide significantly improved measures of bone strength such as failure load and stiffness.
- The research found that patients who responded well to lenalidomide treatment experienced notable gains in bone strength, showcasing the potential benefits of this drug on bone health compared to bortezomib.
Objectives: To evaluate the effectiveness of the iterative decomposition of water and fat with echo asymmetric and least-squares estimation (IDEAL) MRI to quantify tumour infiltration into the lumbar vertebrae in myeloma patients without visible focal lesions.
Methods: The lumbar spine was examined with 3 T MRI in 24 patients with multiple myeloma and in 26 controls. The fat-signal fraction was calculated as the mean value from three vertebral bodies.