Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model.

Purpose: A sporadic colon cancer mouse model with conditional mutations in adenomatous polyposis coli (Apc) is biologically relevant for human colorectal cancer (CRC). This study aimed to determine the utility and limitations of colonoscopy for evaluating colon tumors in this mouse model.

Methods: We compared the estimates of location, size, and miss rate of tumors detected during colonoscopy with those determined by necropsy.