Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates.

Here we aimed to establish a simple detection method for detecting circulating tumor cells (CTCs) in the blood sample of colorectal cancer (CRC) patients using poly(2-methoxyethyl acrylate) (PMEA)-coated plates. Adhesion test and spike test using CRC cell lines assured efficacy of PMEA coating. A total of 41 patients with pathological stage II-IV CRC were enrolled between January 2018 and September 2022.

Modification of a Polymer Surface by Partial Swelling Using Nonsolvents.

Surface modification without changing the physical properties in the bulk is of pivotal importance for the development of polymers as devices. We recently proposed a simple surface functionalization method for polymer films by partial swelling using a nonsolvent and demonstrated the incorporation of poly(2-methoxyethyl acrylate) (PMEA), which has an excellent antibiofouling ability, only into the outermost region of a poly(methyl methacrylate) (PMMA) film. We here extend this technology to another versatile polymer, polystyrene (PS).

A Facile Surface Functionalization Method for Polymers Using a Nonsolvent.

Surface treatment of polymeric solids without impairing their bulk properties is a crucial functionalization strategy for the promotion of their wider application. We here propose a facile method using a nonsolvent which can subtly alter or swell the polymer surface to be modified. A thin film of poly(methyl methacrylate) (PMMA) was immersed in a methanol solution of poly(2-methoxyethyl acrylate) (PMEA).