Mechanical and Thermal ON-OFF Switching of the Vapochromic Behavior of a Luminescent Polymorphic Pt(II) Complex.

Vapochromic materials that exhibit color/luminescence changes induced by vapor exposure have attracted considerable attention. Herein, we report the grinding- and heating-induced ON-OFF switching of the vapochromic behavior of [Pt(ppyCl)(Clacac)] (; ppyCl = 2-(3-chlorophenyl)-4-chloropyridinato, Clacac = 3-chloroacetylacetonato). formed yellow and orange polymorphs ( and ), and could be converted to , which showed a very similar crystal structure but with a broadened X-ray diffraction pattern compared with that of .

Coordination-based vapochromic behavior of a luminescent Pt(ii) complex with potassium ions.

Vapochromic Pt(ii) complexes that exhibit color and luminescence changes induced by the presence of vapor molecules have drawn considerable attention because of their potential use as vapor sensors. Generally, the vapochromic responsiveness of Pt(ii)-based complexes is difficult to envisage, because a typical molecular design facilitates the stabilization of a vapor-adsorbed form through weak intermolecular interactions. Herein, we investigate the vapochromic behavior of a Pt(ii) complex with potassium ions, which act as vapor coordination sites, by strongly stabilizing the vapor-adsorbed form.

Efficacy and Safety of Vibegron Add-on Therapy in Men With Persistent Storage Symptoms After Receiving Alpha 1-Blocker or Phosphodiesterase 5 Inhibitor: A Preliminary Study.

Objective: To investigate the efficacy and safety of vibegron add-on therapy in men with persistent storage symptoms receiving α-1 blockers or PDE5 inhibitor for benign prostatic hyperplasia and then determine the independent factors affecting the efficacy of vibegron.

Methods: Vibegron 50 mg was administered for 12 weeks to 42 patients (72.0 ± 8.

Liquid-liquid interface-promoted formation of a porous molecular crystal based on a luminescent platinum(II) complex.

Porous molecular crystals (PMCs) should function as new-generation functional porous materials, but the selective crystallisation of PMCs is still difficult. Herein we demonstrate that the liquid-liquid interface between the MeOH/H2O mixture and alkanes promotes the crystallisation of a Pt(ii)-based PMC, rather than the nonporous form. This new crystallisation method allows control of not only the porosity but also the luminescence of the Pt(ii) complex crystal.

Bright Luminescent Platinum(II)-Biaryl Emitters Synthesized Without Air-Sensitive Reagents.

Transition-metal complexes bearing biaryl-2,2'-diyl ligands tend to show intense luminescence. However, difficulties in synthesis have prevented their further functionalization and practical applications. Herein, a series of platinum(II) complexes bearing biaryl-2,2'-diyl ligands, which have never been prepared in air, were synthesized through transmetalation and successive cyclometalation of biarylboronic acids.

Tadalafil is sufficiently effective for severe chronic prostatitis/chronic pelvic pain syndrome in patients with benign prostatic hyperplasia.

Objectives: To investigate the efficacy of tadalafil for patients with benign prostatic hyperplasia and chronic prostatitis/chronic pelvic pain syndrome.

Methods: Tadalafil 5 mg was given each morning for 12 weeks to patients diagnosed as having either moderate or severe lower urinary tract symptoms. Voiding symptoms were compared between patients with a high (≥4; high group) and low (<4; low group) pain subscore of the National Institutes of Health Chronic Prostatitis Symptom Index before and after tadalafil administration.

Stability Tuning of Vapor-Adsorbed State of Vapochromic Pt(II) Complex by Introduction of Chiral Moiety.

New luminescent Pt(II) complexes with chiral ester chains, [PtCl( R, R-bpybe)] (R-1; bpybe = 2,2'-bipyridine-4,4'-dicarboxylic acid dibutyl ester) and its racemic mixture (rac-1) with the chiral isomer, S-1, were synthesized, and their vapochromic behavior was investigated. Single-crystal X-ray structural analysis revealed that the rac-1 crystal was composed of only one crystallographically independent column formed by alternating stacking of R-1 and S-1 by the effective intermolecular Pt···Pt interaction. In contrast, three types of columnar structures with different Pt···Pt interactions were found for the R-1 crystal, probably because of the different packing of the chiral ester chains between the columns.

Quantitative Solvent-Free Thermal Synthesis of Luminescent Cu(I) Coordination Polymers.

The luminescent Cu(I) coordination polymers [CuI( m, m'-bpy)] (CuI- m; m, m'-bpy = m, m'-bipyridine; m = 3, 4) were successfully synthesized by the solvent-free thermal reaction of the metal salt CuI with the organic linkers m, m'-bpy. Powder X-ray diffraction analysis revealed that CuI-3 was immediately formed when a mixture of CuI and 3,3'-bpy was ground in a mortar at room temperature (20 °C). In contrast, a temperature >120 °C was required to synthesize the CuI-4 isomer, probably because of the higher melting point of the 4,4'-bpy linker.

Two-way vapochromism of a luminescent platinum(ii) complex with phosphonic-acid-functionalized bipyridine ligand.

A luminescent Pt(ii) complex [Pt(CN)(Hdpbpy)] (1P; Hdpbpy = 2,2'-bipyridine-4,4'-diphosphonic acid) bearing a phosphonic-acid-functionalized bipyridine ligand was successfully synthesized and its unique two-way vapochromic behaviour investigated. X-ray structure analyses of both the anhydrous 1P and penta-hydrated 1P·5H2O phases clearly reveal the activation of intermolecular PtPt interactions through the adsorption of water vapour. Emission spectroscopy reveals that the penta-hydrated 1P·5H2O complex exhibits an orange emission at 585 nm that shifts in two directions, to a blue-green emission at 469 nm by drying at 100 °C or to a red emission at 701 nm by drying under vacuum at room temperature.

Methanol-Triggered Vapochromism Coupled with Solid-State Spin Switching in a Nickel(II)-Quinonoid Complex.

A highly methanol-selective vapochromic response has been realized in a Ni -quinonoid complex, [Ni(HL ) ] (H L =4-methylamino-6-methyliminio-3-oxocyclohexa-1,4-dien-1-olate) which exhibits a reversible structural transformation including a coordination geometrical change between the square-planar and octahedral structure by the selective uptake of methanol vapor. This was accompanied by a remarkable color change between purple and orange, as well as temperature-robust spin-state switching in the solid state under ambient conditions. It is remarkable that the properties are derived by the fine structural modification of the quinonoid ligand such as methyl or ethyl analogues.

Proton-switchable vapochromic behaviour of a platinum(ii)-carboxy-terpyridine complex.

We synthesized a carboxy-substituted Pt(ii)-terpyridine complex, i.e. [PtCl(Hctpy)]Cl ([1H]Cl; Hctpy = 4'-carboxy-2,2':6',2''-terpyridine), that shows interesting switchable vapochromic behaviour upon protonation/deprotonation of the carboxy group.

Shape-Memory Platinum(II) Complexes: Intelligent Vapor-History Sensor with ON-OFF Switching Function.

A novel platinum(II)-diimine complex, [Pt(CN)2 (H2 dcphen)] (1; H2 dcphen=4,7-dicarboxy-1,10- phenanthroline), was synthesized and its vapochromic shape-memory behavior was evaluated. The as-synthesized amorphous purple solid, [Pt(CN)2 (H2 dcphen)]⋅2 H2 O (1 P), exhibited vapochromic behavior in the presence of alcoholic vapors through transformation to a red, crystalline, porous, vapor-adsorbed form, 1 R⊃vapor. The obtained 1 R⊃vapor complex released the adsorbed vapors upon heating without collapse of the porous structure.

Occult hepatitis B virus infection in Japanese chronic hemodialysis patients.

We investigated the prevalence of occult hepatitis B virus (HBV) infection in Japanese chronic hemodialysis patients. Hemodialysis patients (n = 1041) were screened for occult HBV. The presence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody, and hepatitis B core antibody (anti-HBc) was determined by various chemiluminescent immunoassays.

A novel role of the C-terminus of b 0,+ AT in the ER-Golgi trafficking of the rBAT-b 0,+ AT heterodimeric amino acid transporter.

The heterodimeric complex composed of rBAT (related to b(0,+) amino acid transporter), a single-membrane-spanning glycosylated heavy chain, and b(0,+)AT, a putative 12-membrane-spanning non-glycosylated light chain, is an amino acid transporter that mediates the activity of system b(0,+), a major apical transport system for cystine and dibasic amino acids in renal proximal tubule and small intestine. The C-terminus of b(0,+)AT has been proposed to play an important role in the functional expression of the heterodimeric transporters. In the present study, to reveal the roles of the C-terminus, we analysed b(0,+)AT mutants whose C-termini were sequentially deleted or replaced by site-directed mutagenesis in polarized MDCKII (Madin-Darby canine kidney II), non-polarized HEK-293 (human embryonic kidney-293) and HeLa cells.

Molecular identification of a renal urate anion exchanger that regulates blood urate levels.

Urate, a naturally occurring product of purine metabolism, is a scavenger of biological oxidants implicated in numerous disease processes, as demonstrated by its capacity of neuroprotection. It is present at higher levels in human blood (200 500 microM) than in other mammals, because humans have an effective renal urate reabsorption system, despite their evolutionary loss of hepatic uricase by mutational silencing. The molecular basis for urate handling in the human kidney remains unclear because of difficulties in understanding diverse urate transport systems and species differences.

Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains.

We identified a novel Na(+)-independent acidic amino acid transporter designated AGT1 (aspartate/glutamate transporter 1). AGT1 exhibits the highest sequence similarity (48% identity) to the Na(+)-independent small neutral amino acid transporter Asc (asc-type amino acid transporter)-2 a member of the heterodimeric amino acid transporter family presumed to be associated with unknown heavy chains (Chairoungdua, A., Kanai, Y.