Publications by authors named "Yasuhiro Nagate"
An 84-year-old Japanese man was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN). We administered combination therapy using venetoclax and azacytidine. We observed neutropenia (Grade 4), thrombocytopenia (Grade 2), and stomatitis (Grade 3).
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- A 75-year-old man presented with head masses and a spine fracture; tests showed high immunoglobulin G (IgG) levels and monoclonal IgGκ.
- Imaging revealed multiple bone lesions, but a bone marrow sample showed only a small percentage of plasma cells.
- He was diagnosed with plasmablastic lymphoma (PBL), characterized by aggressive B-cell behavior but lacking B-cell antigens, and recovered fully after receiving DA-EPOCH treatment, confirmed by Epstein-Barr virus positivity.
Anamorsin (AM) is an anti-apoptotic molecule cloned by us as a molecule that confers resistance against apoptosis induced by growth factor deprivation. AM-deficient mice are embryonic lethal, which impedes detailed analyses of the roles of AM in various types of adult cells. To overcome the embryonic lethality, we generated AM conditional knockout (AM) mice and cell type-specific genetic modification became possible using the Cre-loxP system.
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- * Two heavily treated elderly patients responded well to this sequential therapy, achieving complete molecular remission without severe side effects typically associated with other treatments.
- * The therapy shows potential as a bridging regimen before allogeneic stem cell transplantation, although further preventative measures for central nervous system issues are recommended.
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- * A 56-year-old man with advanced melanoma developed swelling in his lymph nodes and anemia after receiving nivolumab treatment, but tests showed no signs of cancer.
- * The patient was diagnosed with reactive lymphadenopathy caused by nivolumab, and he was treated with corticosteroids, which successfully resolved the symptoms.
Adult T-cell leukemia/lymphoma (ATLL) patients have an extremely poor prognosis, partly due to their immunosuppressive state. The majority of ATLL patients have leukemic cells with phenotype similar to Tregs, prompting suggestions that ATLL cells themselves have immunosuppressive functions. In this study, we detected CD39 expression on ATLL cells, particularly frequent on aggressive subtypes.
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- The study focuses on the role of myeloid lineage-related antigens in hematopoietic stem/progenitor cells (HSPCs) to better understand hematopoiesis and improve diagnosis and treatment of myeloid cancers.
- Researchers found that SATB1, a chromatin organizer, influences differentiation in HSPCs, leading to the discovery that the molecule Ms4a3 is significantly downregulated when SATB1 is overexpressed.
- Ms4a3 is absent in hematopoietic stem cells but increases with myeloid differentiation, indicating it can effectively distinguish granulocyte/macrophage lineage-committed progenitors, which helps monitor early stages of myeloid
We report a 39-year-old man with intravascular large B-cell lymphoma (IVLBCL) who had been treated as a case with pulmonary arterial hypertension (PAH) for one year. After he became worse, diffuse pulmonary (18)F-fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) suggested the existence of IVLBCL in the lung showing normal CT images. The diagnosis was confirmed with random transbronchial lung biopsy, and he was then successfully treated.
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