Leukoaraiosis significantly worsens driving performance of ordinary older drivers.

Background: Leukoaraiosis is defined as extracellular space caused mainly by atherosclerotic or demyelinated changes in the brain tissue and is commonly found in the brains of healthy older people. A significant association between leukoaraiosis and traffic crashes was reported in our previous study; however, the reason for this is still unclear.

Method: This paper presents a comprehensive evaluation of driving performance in ordinary older drivers with leukoaraiosis.