Publications by authors named "Yasuaki Sawashita"
Article Synopsis
- Myocardial ischemia/reperfusion (I/R) injury leads to additional heart damage even after successful treatment, primarily due to inflammation, and the effects of the herbal medicine Rikkunshito (RKT) on this injury are being explored.
- Mice were divided into groups receiving either RKT or distilled water, then subjected to I/R injury, to assess RKT's potential protective effects by measuring cardiac cytokine levels and infarct size.
- Results showed that RKT pre-treatment reduced specific inflammatory cytokine levels but did not significantly lower infarct size or affect markers indicative of heart strain, suggesting limited cardioprotective benefits.
Article Synopsis
- The study investigated early predictive parameters for maximum amplitude in the kaolin with heparinase assay (HKH) during cardiovascular surgeries involving cardiopulmonary bypass (CPB).
- Data from 23 patients were analyzed, revealing strong correlations between the parameters K and angle with maximum amplitude, indicating their potential utility in predicting coagulation outcomes.
- The findings highlight that K and angle, along with maximum amplitude, can provide valuable insights for making quick decisions about coagulation management in surgical settings.
Myocardial ischemia-reperfusion (I/R) injury induces endothelial glycocalyx (GCX) degradation. Several candidate GCX-protective factors including albumin have been identified, few have been demonstrated in in vivo studies and most albumins used to date have been heterologous. Albumin is a carrier protein for sphingosine 1-phosphate (S1P), which has protective effects on the cardiovascular system.
View Article and Find Full Text PDFBackground: Radial artery is the preferred site for cannulation. Recently, the ulnar artery was chosen as an alternative in adults.
Aims: We aimed to measure the diameter and depth of the ulnar and radial arteries using ultrasound, and our secondary purpose was to evaluate their anatomical position using a near-infrared transcutaneous illumination device.
Remimazolam, a novel and ultrashort-acting benzodiazepine, has been available for general anesthesia in Japan. The administration of remimazolam does not induce injection pain, has been reported to have less cardiovascular depressant effects during general anesthesia, and flumazenil can antagonize the effects of remimazolam. However, in clinical trials, no patient who is complicated with severe heart failure or undergoes cardiac surgery was included.
View Article and Find Full Text PDFBackground: Chronic and/or intermittent exposure to hypobaric hypoxia reportedly exerts cardioprotective effects against ischemia-reperfusion injury. However, few studies have focused on the cardioprotective effects of acute and/or short-term hypobaric and hypoxic exposures. This study investigated the effects of acute hypobaric hypoxia on myocardial ischemia-reperfusion injury.
View Article and Find Full Text PDFRemote ischemic preconditioning (RIPC) offers cardioprotection against myocardial ischemia-reperfusion injury. The humoral factors involved in RIPC that are released from parasympathetically innervated organs have not been identified. Previous studies showed that ghrelin, a hormone released from the stomach, is associated with cardioprotection.
View Article and Find Full Text PDFDexmedetomidine (DEX), a highly selective alpha2 adrenergic receptor agonist, directly protects hearts against ischemia/reperfusion (I/R) injury. However, the detailed mechanism has not been fully elucidated. We studied differentially expressed mRNAs and miRNAs after DEX administration in rat hearts by comprehensive analysis.
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