Publications by authors named "Yassine Mahdi"
Background: Monoclonal antibodies represent one option for treatment of COVID-19 early after infection. Although large clinical trials have been successfully conducted, real world data are needed to obtain a realistic assessment of the assumed effect on hospitalization rates.
Methods: For this retrospective, observational study, clinical data were collected in 2021 from outpatients (402) as well as hospitalized patients (350) receiving monoclonal antibodies Bamlanivimab, Casirivimab/Imdevimab or Etesevimab/Bamlanivimab.
Article Synopsis
- The study focused on improving the evaluation of pharmaceutical granulation processes using a conical fluid bed granulator, specifically through in-situ and spray-on fluid bed melt granulation techniques.
- The research identified key temperature zones during the granulation process, which helped determine optimal conditions for granule growth by analyzing binder properties and spray conditions.
- Findings revealed that the shape and size of the wetting zone significantly influence granule quality, with specific parameters for binder use leading to improved granule size and distribution.
Article Synopsis
- A new in-line measurement technique was developed to monitor air temperature distribution during a granulation process in a conical fluidized bed, enhancing Process Analytical Technology (PAT).
- Three sets of thermocouples captured temperature data continuously, enabling real-time monitoring while PVP solution was sprayed on lactose powder to understand temperature profiles and bed behavior.
- The application of Artificial Neural Networks (ANNs) allowed for accurate predictions of temperature effects due to process variables, showing alignment with actual measurements and suggesting the potential use of this method for predictive control in granulation processes.