Gold nanoparticles anchored graphitized carbon nanofibers ionic liquid electrode for ultrasensitive and selective electrochemical sensing of anticancer drug irinotecan.

An electrochemical sensor is described for highly sensitive and selective determination of anticancer drug irinitecan (IRT). Gold nanoparticles anchored graphitized carbon nanofibers (Au@GCNFs) was prepared. Au@GCNFs was characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray.

Synergistic electrocatalytic activity of InO@FMWCNTs nanocomposite for electrochemical quantification of dobutamine in clinical patient blood and in injection dosage form.

Dobutamine (DBT) is a sympathomimetic amine drug that was designed as an inotropic agent for use in congestive heart failure. Hence, there was an impetus to develop a rapid and accurate method for monitoring the concentration of DBT within clinical samples. To address this critical need, a novel InO and functionalized multi-walled carbon nanotubes nanocomposite (InO@FMWCNTs) was successfully prepared and applied in an electrochemical sensor to detect DBT.

A novel megestrol acetate electrochemical sensor based on conducting functionalized acetylene black-CeONPs nanohybrids decorated glassy carbon microspheres.

For the first time, megestrol acetate (MGA), a synthetic progestin with therapeutic use in breast cancer, is electrochemically studied to propose a new electroanalytical alternative for its detection in real samples. In the present work, a novel electrochemical sensor based on functionalized acetylene black-CeONPs nanohybrids modified glassy carbon microspheres paste electrode (FAB-CeONPs/GCMPE) was successfully fabricated and used for sensitive determination of MGA. The modified electrode has been characterized using scanning electron microscope (SEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS).

Comparative studies on the interaction of anticancer drug irinotecan with dsDNA and ssDNA.

A systematic comparative study on the binding of anticancer drug irinotecan (Irino) with dsDNA and ssDNA was investigated in phosphate buffer solutions using voltammetric and spectroscopic methods. The voltammetric results show that the Irino molecule, acting as an intercalator, is inserted into the base stacking domain of the DNA double helix and the strength of interaction is independent of the ionic strength. The hyperchromic effect observed in the UV-visible spectra of Irino in the presence of dsDNA provided the evidence for the intercalation of the drug chromophore with dsDNA base.

A novel sensor based on nanobiocomposite Au--InO--chitosan modified acetylene black paste electrode for sensitive detection of antimycotic ciclopirox olamine.

For the first time, a sensitive conductive nanobiocomposite sensor consisting of Au-InO nanocomposite and chitosan (CS) was successfully prepared and used for the modification of acetylene black paste electrode (Au--InO--CS/ABPE). The phase structures, composition and morphology of Au-InO nanocomposite were characterized by X-ray diffraction (XRD), energy-dispersed X-ray (EDX) and transmission electron microscopy (TEM). Electrochemical activities and surface analysis of the biosensor electrode Au--InO--CS/ABPE were investigated using scanning electron microscopy (SEM), cyclic voltammetry and square wave voltammetry.

Interactions of an anticancer drug Formestane with single and double stranded DNA at physiological conditions.

Mode of interactions of anticancer drug Formestane (FMT) with single and double stranded DNA has been investigated at different temperatures and at two physiological pH values i.e. 7.

Binding mode and thermodynamic studies on the interaction of the anticancer drug dacarbazine and dacarbazine-Cu(II) complex with single and double stranded DNA.

The binding mode and thermodynamic characteristics of the anticancer drug dacarbazine (Dac) with double and single stranded DNA were investigated in the absence and presence of Cu(II) using cyclic voltammetry, square wave voltammetry and fluorescence spectroscopy. The interaction of Dac and Dac-Cu(II) complex with dsDNA indicated their intercalation into the base stacking domain of dsDNA double helix and the strength of interaction is independent on the ionic strength. The interaction of Dac with dsDNA in the presence of Cu(II) leads to a much stronger intercalation.

Differential pulse polarographic determination of poly(8-hydroxyquinoline) in the presence and absence of an insulating poly(vinyl alcohol) matrix.

The electrochemical activity of poly(8-hydroxyquinoline) (PHQ) in acid and alkaline media has been investigated by use of differential pulse polarography (DPP). The reduction peak height (I(p)) of PHQ in universal buffer solutions is not useful as an analytical signal, because it is highly affected by hydrogen evolution in acid media and appears as a small peak located at more negative potential values in alkaline media. A new and highly sensitive reduction peak (E(p)=-0.