Publications by authors named "Yasser Mohamed Helmy"
Article Synopsis
- Hydroxyapatite nanoparticles (HANPs) are widely used in biomedicine but their neurotoxicity is not well understood; this study investigates that and explores the protective effects of chitosan nanoparticles (CNPs) and curcumin nanoparticles (CUNPs).
- The results show that HANPs dramatically reduce levels of key neurotransmitters and disrupt mitochondrial gene expression, leading to neuroinflammation and increased oxidative stress in exposed rats.
- Co-supplementing with CNPs and CUNPs effectively counteracts the negative effects of HANPs, with their combined use proving more protective than either one alone.
Although the toxicity/biocompatibility of hydroxyapatite nanoparticles (HAPNPs), a prospective nano-biomaterial, is extensively studied, its interaction on the reproductive system following exposure is less exploited. In the present study, male rats were exposed to HAPNPs (300 mg/kg BW) to determine its possible reproductive toxicity. Also, the protective effects of chitosan (CSNPs, 280 mg/kg BW) and/or curcumin (CurNPs, 15 mg/kg BW) nanoparticles against HAPNPs-induced reproductive toxicity were studied.
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