Recognition of 7 genes signature (Cirrhosis Risk Score) in the diagnosed non-responders to DAAs therapy by intra-PBMCs nested HCV RNA PCR.

Background And Aims: Predictors of chronic HCV response to oral antiviral therapy (OAT) are related to host genetic variations. Single nucleotide polymorphisms (SNP) and alleles variations of host genes in association with hepatic fibro-cirrhotic changes have a distinct role in OAT outcomes. The current research evaluated the association of Cirrhosis-Risk-Scores (CRS) values, based on the correlation of seven genes signature-SNPs, with sonographic liver parenchymal changes in determining OAT outcomes.

Evaluation of rifaximin in management of hepatic encephalopathy.

This study evaluated the efficacy of rifaximin versus lactulose in the treatment of hepatic encephalopathy (HE). The study population included 50 patients who were diagnosed to have signs of the first to third degree HE, according to the West Haven criteria and classified into two groups. GI: included 25 patients who had HE and were treated with lactulose syrup (laxolac) 90 ml daily divided into 3 doses for 7 days.

Natural infection of baboons by Entamoeba histolytica elicits anti- gal-lectin heavy subunit IgA and IgG antibodies with shared epitope specificity to that of humans.

Non-human primates, such as baboons (Papio hamadryas anubis), are natural hosts for Entamoeba species; infections can be asymptomatic or result in invasive lethal disease. It was sought to determine whether following natural infection by Entamoeba. histolytica, baboon anti-amebic antibodies recognized native Gallectin, a recombinant portion of the lectin heavy subunit (designated LC3) and specific heavy subunit epitopes; we compared the specificity of anti-amebic antibodies from baboons to that of humans following asymptomatic E.

Prognostic and predictive values of MELD score, platelet count and pre-albumin in patients with compensated and decompensated liver cirrhosis with acute variceal bleeding.

The study included 190 patients divided in to 5 groups: 20 normal as healthy control complaining of dyspepsia, GERD etc., 20 patients positive HCV without cirrhosis or varices, 50 patients compensated cirrhosis with varices, 50 patients decompensated cirrhosis with varices and 50 patients with primary acute variceal bleeding. All were subjected to full history taking, clinical examination, routine laboratory examinations including serum pre-albumin, abdominal ultrasonography, MELD score was calculated for all patients, Child classification for all patient and upper gastrointestinal endoscopy.