Publications by authors named "Yasser Bm Ali"
Article Synopsis
- * Key genotypes and alleles linked to RA susceptibility include GC, IL-6-174 C allele, miR-146a CG, and MALAT1 AA, indicating they may serve as risk factors.
- * Increased expression levels of IL-6, miR-146a, and MALAT1 were found in RA patients, suggesting a potential role in the disease that is not solely dependent on the identified SNPs.
microRNA-146a (miR-146a) plays an essential role in immune anomalies and organ injury of systemic lupus erythematosus (SLE) by regulating the disease's inflammation and complications. Here, we analyzed the expression of miR-146a in SLE and a panel of pro-inflammatory cytokines (IL-1, IL-6, IL-8, IL-17, and TNF-α). Association between all measured parameters and the disease's clinical manifestation and response to treatment was monitored.
View Article and Find Full Text PDFBackground: Bevacizumab (Bev) resistance is hypothesized to be overcome by combining inhibitors of other signalling pathways.
Objective: We aimed to study the effect of combining Bev with knocked down β-catenin (Bev-β-cat-siRNA) on the expression of VEGF-A, Slug, NFκB, and its two target genes, c-Flip and FasR, in HepG2. Expression of VEGF-A and Slug was also studied in Caco-2 cells.