Quantification of Color Variation of Various Esthetic Restorative Materials in Pediatric Dentistry.

Aim Of Study: The goal of this paper is to find an association between the staining capacity of dental restorations used in pediatric patients and food items and to develop an optimum model to predict the most informative factor that causes the highest amount of color change through machine learning algorithms.

Background: Color changes in restorative materials occur as a result of intrinsic and extrinsic factors, such as the type of restorative material, food items used, polished status of the material, and time interval.

Materials And Methods: This was an " study" conducted at Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Chitosan-based hydrogel system for efficient removal of Cu[II] and sustainable utilization of spent adsorbent as a catalyst for environmental applications.

The growing requirement for clean potable water requires sustainable methods of eliminating heavy metal ions and other organic contaminants. Herein, we synthesized a novel dual-purpose magnetically separable chitosan-based hydrogel system (CSGO-R@IO) that can efficiently remove toxic Cu pollutants from water. FT-IR, XRD, SEM-EDX, VSM, XPS analyses were used to characterize the synthesized hydrogel.

Diffusion tensor imaging and auditory tractography to evaluate cochlear implant candidacy: a pilot study.

Background: Conventional radiological evaluation does not evaluate the functional status of the auditory pathway in patients scheduled for cochlear implantation (CI).

Objectives: Determine the value of diffusion tensor imaging [DTI] in the preoperative evaluation of some patients scheduled for CI.

Material And Methods: Patients with profound SNHL and inner ear and/or cochlear nerve anomalies or long standing SNHL were selected.

In acid-aminopyrimidine continuum: experimental and computational studies of furan tetracarboxylate-2-aminopyrimidinium salt.

Salts and cocrystals are the two important solid forms when a carboxylic acid crystallizes with an aminopyrimidine base such that the extent of proton transfer distinguishes between them. The Δp value (p (base) - p (acid)) predicts whether the proton transfer will occur or not. However, the Δp range, 0 < Δp < 3, is elusive where the formation of cocrystal or salt cannot be predicted.

Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs.

The focus of the review is to discuss the relevant and essential aspects of pharmaceutical cocrystals in both academia and industry with an emphasis on non-steroidal anti-inflammatory drugs (NSAIDs). Although cocrystals have been prepared for a plethora of drugs, NSAID cocrystals are focused due to their humongous application in different fields of medication such as antipyretic, anti-inflammatory, analgesic, antiplatelet, antitumor, and anti-carcinogenic drugs. The highlights of the review are (a) background of cocrystals and other solid forms of an active pharmaceutical ingredient (API) based on the principles of crystal engineering, (b) why cocrystals are an excellent opportunity in the pharma industry, (c) common methods of preparation of cocrystals from the lab scale to bulk quantity, (d) some latest case studies of NSAIDs which have shown better physicochemical properties for example; mechanical properties (tabletability), hydration, solubility, bioavailability, and permeability, and (e) latest guidelines of the US FDA and EMA opening new opportunities and challenges.

The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.

Rectal cancer is a common malignancy with a relatively poor prognosis. We assessed the possible prognostic and predictive role(s) of circulating tumor cells (CTCs) and K-ras mutations in locally advanced rectal carcinoma (LARC) patients. CTCs number and K-ras mutation status were assessed in the Peripheral blood and tumor tissue samples of 60 patients with LARC compared to control group (normal rectal mucosa).

Sulfaguanidine cocrystals: Synthesis, structural characterization and their antibacterial and hemolytic analysis.

Sulfaguanidine (SG), belongs to the class of sulfonamide drug used as an effective antibiotic. In the present work, using crystal engineering approach two novel cocrystals of SG were synthesized (SG-TBA and SG-PT) with thiobarbutaric acid (TBA) and 1,10-phenanthroline (PT), characterized by solid state techniques viz., powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and the crystal structures were determined by single crystal X-ray diffraction studies.

Molecular complexes of alprazolam with carboxylic acids, boric acid, boronic acids, and phenols. Evaluation of supramolecular heterosynthons mediated by a triazole ring.

A series of molecular complexes, both co-crystals and salts, of a triazole drug-alprazolam-with carboxylic acids, boric acid, boronic acids, and phenols have been analyzed with respect to heterosynthons present in the crystal structures. In all cases, the triazole ring behaves as an efficient hydrogen bond acceptor with the acidic coformers. The hydrogen bond patterns exhibited with aromatic carboxylic acids were found to depend on the nature and position of the substituents.

Synthesis, characterization of complexes of Co(II), Ni(II), Cu(II) and Zn(II) with 12-membered Schiff base tetraazamacrocyclic ligand and the study of their antimicrobial and reducing power.

Schiff base tetraazamacrocyclic ligand, L (C(40)H(28)N(4)) and its complexes of types, [MLX(2)] and [CuL]X(2) (M=Co(II), Ni(II), Zn(II); X=Cl(-), NO(3)(-)) were synthesized and characterized by elemental analyses, mass, (1)H NMR, IR, UV-vis, magnetic susceptibility and molar conductance data. An octahedral geometry has been proposed for all the complexes except the copper(II) complexes which have a square planar environment. The reducing power of the Co(II) and Cu(II) complexes have been checked and compared.