Publications by authors named "Yassamin N Albayaty"

Infections caused by fungal biofilms with rapidly evolving resistance against the available antifungal agents are difficult to manage. These difficulties demand new strategies for effective eradication of biofilms from both biological and inert surfaces. In this study, polymeric micelles comprised of di-block polymer, poly-(ethylene glycol) methyl ether methacrylate and poly 2-(N,N-diethylamino) ethyl methacrylate polymer, P(PEGMA-b-DEAEMA), were observed to exhibit remarkable inhibitory effects on hyphal growth of Candida albicans (C.

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Candida albicans (C. albicans) is a common fungal pathogen causing both localised and systemic infections. The majority of these infections are promoted by biofilm formation, providing a protective matrix for the embedded fungi thereby evading the host immune defence and promoting resistance against anti-mycotic agents.

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Staphylococcal biofilms cause many infectious diseases and are highly tolerant to the effects of antimicrobials; this is partly due to the biofilm matrix, which acts as a physical barrier retarding the penetration and reducing susceptibility to antimicrobials, thereby decreasing successful treatment outcomes. In this study, both single and mixed micellar systems based on poly vinyl caprolactam (PCL)-polyethylene glycol (PEG) copolymers were optimised for delivery of chlorhexidine (CHX) to S. aureus, MRSA and S.

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Synopsis of recent research by authors named "Yassamin N Albayaty"

  • - Yassamin N Albayaty's research focuses on developing innovative polymeric micelles to combat biofilms formed by pathogenic fungi and bacteria, such as Candida albicans and Staphylococcus aureus, which exhibit high resistance to traditional antimicrobial treatments.
  • - Recent studies demonstrate the effectiveness of various pH-responsive and enzyme-responsive copolymer micelles that enhance the efficacy of antifungal agents like itraconazole and antiseptics like chlorhexidine against biofilm-associated infections.
  • - The findings underscore the potential of these micellar systems in overcoming biofilm-induced challenges in therapeutic contexts, paving the way for new strategies to improve treatment outcomes for persistent infections.*