Publications by authors named "Yasmine Salman"
Amygdala atrophies in specific subnuclei in preclinical Alzheimer's disease.
Alzheimers Dement
October 2024
Article Synopsis
- MRI segmentation algorithms allow detailed study of MTL structures, aiding in the search for preclinical Alzheimer’s disease (AD) biomarkers.
- In a study of 581 non-demented individuals, certain amygdala subnuclei were linked to tau deposits, but global brain volumes showed no significant changes.
- Specific atrophy in amygdala subnuclei may indicate early signs of tauopathy in individuals at risk for developing AD, while overall hippocampal volumes were not correlated with tau levels.*
Purpose: [F]MK-6240, a second-generation tau PET tracer, is increasingly used for the detection and the quantification of in vivo cerebral tauopathy in Alzheimer's disease (AD). Given that neurological symptoms are better explained by the topography rather than by the nature of brain lesions, our study aimed to evaluate whether cognitive impairment would be more closely associated with the spatial extent than with the intensity of tau-PET signal, as measured by the standard uptake value ratio (SUVr).
Methods: [F]MK6240 tau-PET data from 82 participants in the AD spectrum were quantified in three different brain regions (Braak ≤ 2, Braak ≤ 4, and Braak ≤ 6) using SUVr and the extent of tauopathy (EOT, percentage of voxels with SUVr ≥ 1.