Publications by authors named "Yasmine Metaxa"
J Biol Chem
November 2024
Article Synopsis
- A human lectin array has been developed to study how immune receptors interact with various microbes, featuring C-type carbohydrate-recognition domains (CRDs) and other sugar-binding receptors like galectins and siglecs.
- The array is designed using biotin-tagged CRDs, allowing for easy detection of binding interactions on a streptavidin-coated surface, facilitating comparisons across different types of glycan-binding receptors.
- Initial tests show unexpected binding patterns, revealing that some galectins interact strongly with bacterial glycans, highlighting the array's potential to provide new insights into innate immune interactions with diverse microorganisms.
