Publications by authors named "Yasmine Dergham"
Bacillus subtilis can form various types of spatially organised communities on surfaces, such as colonies, pellicles and submerged biofilms. These communities share similarities and differences, and phenotypic heterogeneity has been reported for each type of community. Here, we studied spatial transcriptional heterogeneity across the three types of surface-associated communities.
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- * This strain can protect harmful pathogens in biofilms from biocides, making it a significant concern in healthcare settings.
- * Research involving NDmed aims to enhance our understanding of biofilms and their genetic dynamics, leveraging modern molecular tools to explore complex bacterial behaviors.
is a widely used bacterial model to decipher biofilm formation, genetic determinants and their regulation. For several years, studies were conducted on colonies or pellicles formed at the interface with air, but more recent works showed that non-domesticated strains were able to form thick and structured biofilms on submerged surfaces. Taking advantage of time-lapse confocal laser scanning microscopy, we monitored bacterial colonization on the surface and observed an unexpected biphasic submerged biofilm development.
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- Surface-associated multicellular assemblies, like biofilms, help bacteria survive tough environments, with a focus on the well-researched Gram-positive bacteria NDmed.
- Most research has emphasized biofilms at the air-liquid interface or on agar, but this study examines submerged biofilms and links genetic features across different multicellular models.
- By analyzing 15 mutated strains of NDmed that impact motility and biofilm formation, the study reveals how changes in certain genes affect different biofilm phenotypes and surface behaviors, highlighting the complexities of biofilm development.